家族性地中海熱の子供における神経学的関与:体系的なレビュー
Saverio La Bella1,2, Antonio Corsello3,4, Deniz Bayraktar5,6
1UOC Rheumatology and Autoinflammatory Diseases, IRCCS Istituto Giannina Gaslini, Genova, Italy. drsaveriolabella@gmail.com.
Pediatric rheumatology online journal
|September 2, 2025
まとめ
神経学的な問題は,家族性地中海熱 (FMF) の小児で一般的であり,患者の3分の1以上に影響します. 早期の神経学的評価は FMFの管理と長期的な成果の改善に不可欠です.
科学分野:
- 小児神経学
- リウマトロジ
- 遺伝学
背景:
- 家族性地中海熱 (FMF) は自己炎症性疾患である.
- FMFの典型的な症状には,発熱,腹痛,胸痛があります.
- 子どものFMFにおける神経学的症状は十分に研究されていない.
研究 の 目的:
- FMFの子供の神経学的症状に関する文献を体系的にレビューする.
- 小児 FMF の症例における神経学的関与の流行と種類を決定する.
主な方法:
- PubMed/Medline,Cochrane,Web of Scienceの体系的な文献検索を行った.
- FMFと神経学的症状を持つ18歳未満の患者を対象とした研究を含む.
- PRISMAのガイドラインに従って試験を選択しました.
主要な成果:
- FMFを患った4753人の子供の33. 9%が神経学的関与を経験した.
- 頭痛 (4. 8~58. 8%) と発熱発作 (1~15. 2%) が最も一般的であった.
- 稀に報告された: 脱ミエリン症候群,感覚神経聴覚障害,網膜異常.
結論:
- 神経学的関わりは小児FMFでは頻繁であり,長期の障害を引き起こす可能性があります.
- FMFの管理には 早期に総合的な神経学的評価が不可欠です
- 原因関係を確立し,報告のバイアスを減らすためにさらなる研究が必要である.
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