トリグリセリド糖値と腰の高さ比率と中年および高齢の中国人における心代謝多発性との関連:全国的な前向きコホート研究
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PubMedで要約を見る
まとめ
この要約は機械生成です。トリグリセリド・グルコース (TyG) インデックスと腰高比率 (WHtR) の組み合わせ (TyG-WHtR) は,独立して心代謝多発症 (CMM) リスクを予測します. 高いTyG-WHtRレベルは,CMMの発生率の増加と線形に関連しています.
科学分野
- 心臓病科
- 代謝 健康
- 流行病学
背景
- 心臓代謝多発症 (CMM) は,世界的な健康上の大きな課題です.
- トリグリセリド・グルコース指数 (TyG) と腰高比 (WHtR) は,それぞれインスリン抵抗性および中央脂肪度の確立されたマーカーである.
- TYGとWHtRの組み合わせによるCMMリスク評価に関する研究は限られている.
研究 の 目的
- 組み合わせたTyG-WHtR指数とCMMの発症リスクとの関係を調査する.
- CMMに対するTyG-WHtR指数の予測性能を評価する.
主な方法
- 45歳以上の中国人の前向きなコホート研究 (2011-2020年).
- 分析には,カプラン- メイヤー曲線,多変量コックス回帰,制限立方スライン (RCS) が含まれていた.
- 予測性能は時間依存のROC,NRI,IDI分析を用いて評価された.
主要な成果
- 合計4393人の被験者を分析し,413人 (9. 4%) が平均9年間の追跡期間中にCMMを発症した.
- TyG- WHtR指数の四分数の増加は,徐々に高まるCMMリスク (HRは1. 75から3. 13) と関連付けられました.
- TyG-WHtRインデックスはCMMの独立した予測能力と改善されたリスク再分類指標を示した.
結論
- TyG-WHtR指数は,心臓代謝性多発性リスクの独立した予測値として機能する.
- TyG-WHtRとCMMの発生率は線形的な用量反応関係にある.
- TyG-WHtRは早期リスク評価とCMM予防戦略の可能性を示しています.
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