関連する実験動画

Updated: May 5, 2026

Transposon Mediated Integration of Plasmid DNA into the Subventricular Zone of Neonatal Mice to Generate Novel Models of Glioblastoma
10:58

Transposon Mediated Integration of Plasmid DNA into the Subventricular Zone of Neonatal Mice to Generate Novel Models of Glioblastoma

Published on: February 22, 2015

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転移可能な要素のダイナミクス 膠芽細胞幹細胞:局所特異的定量化からの洞察

Mattia D Pizzagalli1, Yusuke Suita1, Owen P Leary1

  • 1Laboratory of Cancer Epigenetics and Plasticity, Brown University, Providence, RI, USA.

Mobile DNA
|September 2, 2025
PubMed
まとめ

移植可能な要素 (TEs) は,異なる遺伝子発現プロファイルを持つ膠原体幹細胞 (GSC) のサブ集団を定義する. TEの調節を理解することで,膠芽細胞腫の再発に対する潜在的な治療戦略が提供されます.

キーワード:
ERV について遺伝子調節グリオブラストーマLINE について転写因子適用可能な要素

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Co-culture of Glioblastoma Stem-like Cells on Patterned Neurons to Study Migration and Cellular Interactions10:08

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関連する概念動画

Overview of Transposition and Recombination02:13

Overview of Transposition and Recombination

Transposons make up a significant part of genomes of various organisms. Therefore, it is believed that transposition played a major evolutionary role in speciation by changing genome sizes and modifying gene expression patterns. For example, in bacteria, transposition can lead to conferring antibiotic resistance. Movement of transposable elements within the genetic pool of pathogenic bacteria can aid in transfer of antibiotic-resistant genetic elements. In eukaryotes, transposons can carry out...
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Regulated mRNA Transport02:22

Regulated mRNA Transport

In eukaryotes, transcription and translation are compartmentalized; an mRNA is first synthesized in the nucleus and then selectively transported to the cytoplasm for protein synthesis. Before transport, a pre-mRNA undergoes several steps of post-transcriptional modifications including splicing, 5' capping, and the addition of a poly-adenine tail. Various proteins bind to the pre-mRNA during these modifications. The mRNA transport takes place with the help of multiple proteins playing...
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Transposons01:24

Transposons

Transposons, or "jumping genes," are small mobile genetic elements (MGEs) that range from 700 to 40,000 base pairs in length. They are found in all organisms and can move within the same chromosome or transfer to different chromosomes. In some cases, transposons can also jump between different host DNA molecules, such as plasmids or viruses, contributing to genetic variability.Barbara McClintock first discovered these mobile genetic elements in the 1940s while studying maize genetics, and she...
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