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Updated: Sep 9, 2025

Optimization of High Grade Glioma Cell Culture from Surgical Specimens for Use in Clinically Relevant Animal Models and 3D Immunochemistry
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Optimization of High Grade Glioma Cell Culture from Surgical Specimens for Use in Clinically Relevant Animal Models and 3D Immunochemistry

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膠原腫幹細胞のフェノタイプ的変化: 調節機構と治療戦略への影響

Guofeng Tian1, Yifu Song1, Yaochuan Zhang1

  • 1Department of Neurosurgery, The First Hospital of China Medical University, No. 115 Nanjing North Street, Shenyang, 110001, China.

Journal of translational medicine
|September 2, 2025
PubMed
まとめ

このレビューでは,プロニューラル (PN) とメゼンキマル (MES) のサブタイプに焦点を当てて,膠原性幹細胞 (GSC) の可塑性を調査しています. 制御メカニズムと移行を 理解することは 新しい膠原腫治療法の開発の鍵です

キーワード:
グリオマグリオマ 幹細胞メセンキマルプロネウラル信号変換

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Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
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Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
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