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Updated: Sep 9, 2025

Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants
07:38

Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants

Published on: June 6, 2025

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ATE1は,MAPK-MYCシグナル伝達のアルギニレーション依存的調節によって,乳がんの進行を促進する

Laxman Nawale1,2, Shinyeong Ju3, Jung Gi Kim1

  • 1Nucleic Acid Therapeutics Research Center, Korea Research Institute of Bioscience and Biotechnology, Ochang-eup, Cheongju-si, Chungcheongbuk-do, 28116, Republic of Korea.

Cell communication and signaling : CCS
|September 2, 2025
PubMed
まとめ

アルギニル- tRNA- タンパク質トランスファーゼ (ATE1) は,MYCを安定させ,増殖と生存を促進することによって,乳がんの成長を誘導する. ATE1を標的とした治療は,乳がん患者にとって新しい治療戦略となるかもしれません.

キーワード:
ATE1 (アルギニルトランスフェラーゼ1)乳がん細胞増殖細胞生存率MYCシグナリングN-デグロン経路N端のアルギニレーション腫瘍の進行

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