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Updated: May 13, 2026

The Rabbit Model of Accelerated Atherosclerosis: A Methodological Perspective of the Iliac Artery Balloon Injury
09:14

The Rabbit Model of Accelerated Atherosclerosis: A Methodological Perspective of the Iliac Artery Balloon Injury

Published on: October 3, 2017

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[動脈硬化実験用ウサギモデルにおける内生性アンドロゲンの血管および分子効果]

Darío Echeverri1, Mónica Díaz2, Alexandra Delgadillo1

  • 1Laboratorio de Investigación en Función Vascular. Fundación Cardioinfantil-Instituto de Cardiología. Bogotá. Colombia.

Clinica e investigacion en arteriosclerosis : publicacion oficial de la Sociedad Espanola de Arteriosclerosis
|September 3, 2025
PubMed
まとめ

この研究は,内生性テストステロンが動脈硬化症を予防する可能性があることを示唆しています. 誘発性動脈硬化症のウサギのカストレーションにより プラークの形成が悪化し,コレステロール代謝の遺伝子が変化した.

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A Rabbit Venous Interposition Model Mimicking Revascularization Surgery using Vein Grafts to Assess Intimal Hyperplasia under Arterial Blood Pressure

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Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...