機能性消化不全の補足療法としてのShugan Jieyuカプセルの有効性と安全性: 体系的なレビューとメタ解析
Shuangli Peng1, Yamei Ge2, Huiyun Pu2
1Department of Traditional Chinese Medicine, Renmin Hospital of Wuhan University, Wuhan, China.
Medicine
|September 3, 2025
まとめ
機能性消化不全 (FD) の治療効果を大幅に改善し,再発を減少させます. 安全性プロファイルは比較可能だが,さらなる高品質の試験が必要である.
科学分野:
- 胃腸内科
- 統合医療
- 薬理学について
背景:
- 機能性消化不良 (FD) は臨床的に重要な課題です.
- FDの補完的な治療法の評価は,患者のアウトカムを改善するために重要です.
研究 の 目的:
- FDの補助療法としてShugan Jieyuカプセル (SG) の有効性と安全性を評価する.
- FD 治療のための SG のランダム化制御試験 (RCT) の証拠を合成する.
主な方法:
- 7つの電子データベースで体系的な文献検索が行われました.
- RevMan v5. 3とStata 12. 0を用いたメタ解析により,バイアス2ツールによる試験品質の評価が行われました.
主要な成果:
- 3582人の参加者を含む32件のRCTを分析した.
- 併用療法 (SG + 西洋薬) は優れた有効性 (RR=1.29,P<.00001) を示し,再発率は減少した (RR=0.24,P<.00001).
- 胃腸症候群のスコアが有意に改善した (SMD=-1. 59, P<. 00001) で,安全性は同等であった (RR=1. 0, P=. 99).
結論:
- 補足療法としてのSGは,安全性を損なうことなく,FD治療の有効性を高める可能性があります.
- 限界には,方法論の質が低く,現在の研究における民族的多様性が限られている.
- 断定的な結論を出すには,多様な集団を対象とした高品質のマルチセンターRCTが必要です.
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