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Updated: Sep 9, 2025

An In Vivo Mouse Model of Total Intravenous Anesthesia During Cancer Resection Surgery
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悪性腫瘍患者の術後の認知機能に対するセボフルーラン吸入麻酔とプロポホル静脈麻酔の効果:メタ分析

Yuhang Quan1, Mingxiong Zhang2, Mengqiu Zheng3

  • 1Department of Anesthesiology, Yunnan Cancer Hospital, Kunming 650118, Yunnan, China.

Medicine
|September 3, 2025
PubMed
まとめ

セボフルーランとプロポフォール麻酔は,がん患者の術後の認知機能に長期的に同様の効果を持っています. 短期的な影響は異なるが,セボフルランは一時的な認知障害を引き起こす可能性がある.

キーワード:
麻酔認知機能障害悪性腫瘍メタ解析神経心理学的テスト術後の認知合併症プロポポールセボフルラン

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Various sedation levels offer significant advantages in facilitating procedural interventions for patients undergoing medical or invasive surgical procedures. These levels span from anxiolysis to general anesthesia, providing a spectrum of sedative effects to cater to specific patient needs. Anxiolysis reduces anxiety and is achieved through minimal sedation, enabling patients to remain awake and responsive while feeling more at ease during the procedure. This level can benefit minor...
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Anesthesia is a medical procedure that uses drugs for CNS suppression to enable painless surgeries and procedures. The selection of anesthetics is influenced by their pharmacokinetic properties, side effects, and patient characteristics. Various types of anesthesia include general, local, regional, spinal, and inhalational.
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Inhalation anesthetics are drugs that induce general anesthesia upon inhalation. They work by increasing the sensitivity of GABAA receptors or inhibiting NMDA receptors, leading to a decrease in central nervous system activity. The depth of anesthesia can be rapidly adjusted by changing the concentration of the inhaled gas. Some common examples of inhalational anesthetics include volatile liquids like isoflurane, desflurane, sevoflurane and gases like xenon and nitrous oxide. Isoflurane, a...
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Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
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