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Updated: Sep 9, 2025

Assessment of Lymphocyte Migration in an Ex Vivo Transmigration System
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α-トコフェロルは,LKB1に依存した方法でILC2フェロプトーシスを調節することによって,アレルギー性呼吸道炎症を緩和する

Xiaogang Zhang1, Jingping Liu2, Ziyang Chen3

  • 1Pediatric Intensive Care Unit, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences); Department of Immunology, School of Basic Medical Sciences; Department of Clinical Laboratory, the Third Affiliated Hospital of Southern Medical University, Southern Medical University, Guangzhou 510515, China; Department of Immunology, School of Basic Medical Sciences; Guangdong Provincial Key Laboratory of Single-cell and Extracellular Vesicles, Southern Medical University, Guangzhou 510515, China.

Molecular therapy : the journal of the American Society of Gene Therapy
|September 3, 2025
PubMed
まとめ

ビタミンE成分アルファトコフェロール (α-Toc) は,グループ2の先天性リンパ球細胞 (ILC2) のスキャベンジャー受容体クラスB型1 (SCARB1) とLKB1-AMPK/mTOR経路を阻害することによって,アレルギー性呼吸道炎症を調節する. これは,α-トックが潜在的な喘息治療法であることを示唆しています.

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