Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

702
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
702
Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

376
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
376
Neural Regulation01:37

Neural Regulation

39.9K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.9K
Myasthenia Gravis: Overview and Treatment01:20

Myasthenia Gravis: Overview and Treatment

1.9K
Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
1.9K
Myasthenia Gravis: Diagnostic Tests01:15

Myasthenia Gravis: Diagnostic Tests

1.3K
Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
1.3K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Targeted α-synuclein mRNA degradation by PMO-based RNA-degrading chimeras.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same authorSame journal

A Randomized Controlled Trial of Dual Upper-Extremity Training [DUET]: Combining Neurologic Music Therapy® with Noninvasive Brain Stimulation for Upper-Limb Performance in Corticobasal Syndrome.

Movement disorders clinical practice·2026
Same author

<i>LRRK2</i> in Focus: A Global Browser Linking Genetic Diversity to Functional Effects.

medRxiv : the preprint server for health sciences·2026
Same author

Striatal Tau Pathology Underlies Monoaminergic Disruption in Progressive Supranuclear Palsy.

Clinical nuclear medicine·2026
Same author

Regional wasteosome accumulation across neurodegenerative diseases points to a shared underlying mechanism potentially related to glymphatic insufficiency.

Acta neuropathologica communications·2026
Same author

Repeat expansions in Parkinson's disease and parkinsonism across ancestries: insights from a global genetic cohort.

medRxiv : the preprint server for health sciences·2026

関連する実験動画

Updated: Sep 9, 2025

A Quick Phenotypic Neurological Scoring System for Evaluating Disease Progression in the SOD1-G93A Mouse Model of ALS
06:49

A Quick Phenotypic Neurological Scoring System for Evaluating Disease Progression in the SOD1-G93A Mouse Model of ALS

Published on: October 6, 2015

19.9K

漸進的な超核性麻痺-A グローバルレビュー

Prashanth Lingappa Kukkle1, Rosy Neupane1, Alexandar Pantelyat2

  • 1Parkinson's Disease and Movement Disorders Clinic, Bangalore, India.

Movement disorders clinical practice
|September 3, 2025
PubMed
まとめ

進行性超核性麻痺 (PSP) は,世界的に有意な流行および発現の違いを示しています. 診断とケアにおける地域格差を解決することは,世界中の患者の治療結果を改善するために不可欠です.

キーワード:
PSP研究グループクリニカルプロファイルグローバル比較進行性超核性麻痺

さらに関連する動画

Human Neural Organoids for Studying Brain Cancer and Neurodegenerative Diseases
09:36

Human Neural Organoids for Studying Brain Cancer and Neurodegenerative Diseases

Published on: June 28, 2019

10.0K
Author Spotlight: Repetitive Transcranial Magnetic Stimulation Combined with Movement Observation in Cerebral Palsy
07:20

Author Spotlight: Repetitive Transcranial Magnetic Stimulation Combined with Movement Observation in Cerebral Palsy

Published on: August 9, 2024

1.3K

関連する実験動画

Last Updated: Sep 9, 2025

A Quick Phenotypic Neurological Scoring System for Evaluating Disease Progression in the SOD1-G93A Mouse Model of ALS
06:49

A Quick Phenotypic Neurological Scoring System for Evaluating Disease Progression in the SOD1-G93A Mouse Model of ALS

Published on: October 6, 2015

19.9K
Human Neural Organoids for Studying Brain Cancer and Neurodegenerative Diseases
09:36

Human Neural Organoids for Studying Brain Cancer and Neurodegenerative Diseases

Published on: June 28, 2019

10.0K
Author Spotlight: Repetitive Transcranial Magnetic Stimulation Combined with Movement Observation in Cerebral Palsy
07:20

Author Spotlight: Repetitive Transcranial Magnetic Stimulation Combined with Movement Observation in Cerebral Palsy

Published on: August 9, 2024

1.3K

科学分野:

  • 神経科学
  • 流行病学
  • 遺伝学

背景:

  • 進行性超核性麻痺 (PSP) は,異なった臨床的現象型を持つ希少で重度の神経変性タオパシーです.
  • PSPの有病率,臨床表現,および予後については,地域的に大きな差異がある.

研究 の 目的:

  • 世界的な流行病学的変化,臨床的現象型,診断方法,およびPSPの管理戦略を体系的に検討する.
  • PSPにおける地域格差と影響する遺伝的,環境的要因を特定する.

主な方法:

  • PRISMAのガイドラインに従って,広範な文献検索を行いました.
  • PSPの疫学,表型,診断,リスク要因,治療,予後に関する研究の分析.
  • 地域差を考慮して地理的に分類されたデータ

主要な成果:

  • 診断基準や医療インフラの影響を受け,世界全体でPSPの罹患率は10万人に5~6人です.
  • 一般的なPSP症状には 視力麻痺,転倒,認知,運動機能障害があります.
  • 予後はサブタイプによって異なる (例えば,PSP-RS 5-7年,PSP-P 8-12年);遺伝 (MAPT H1ハプロタイプ),環境,および医療へのアクセスにおける地域的な違いが指摘されている.

結論:

  • PSPの流行,表型,医療へのアクセスにおける地域差は,標準化された診断基準を必要とします.
  • 対象となる遺伝子/環境研究と 公平な医療戦略は不可欠です
  • PSPの診断,管理,結果の改善には グローバルな協力が不可欠です