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多発性硬化症における認知結果の説明
Jonadab Dos Santos Silva1,2,3, Claudia C F Vasconcelos4, Carina T Spedo5
1Postgraduate Program in Neurology, Universidade Federal Fluminense, Niterói, Brazil.
まとめ
多発性硬化症 (MS) の認知機能に 大きく影響します ディスコネクトームマッピングは 特定の白質の領域を MS患者の処理速度,言語,視覚空間記憶の欠陥と関連付けています
科学分野:
- 神経科学
- 神経科学
- 医療用イメージング
背景:
- 認知障害は多発性硬化症 (MS) の重大な障害である.
- MS患者の認知欠陥の程度を完全に説明することはできません.
研究 の 目的:
- 病変の間接的な影響を表す脱線症が,病変負荷と比較してMSにおける多領域認知欠陥をよりよく説明できるかどうかを調査する.
- 多発性硬化症の認知障害に関連する特定の白質の経路を特定する.
主な方法:
- MSを患っている30人の成人は,処理速度 (シンボル・ディジット・モダリティス・テスト; SDMT),言語記憶 (カリフォルニア・バーバル・ラーニング・テストII; CVLT-II),視覚空間記憶 (Brief Visuospatial Memory Test-Revised; BVMT-R) を含む認知評価を受けました.
- 損傷は3つのテスラ流体弱化逆転回復MRIスキャンから分割されました.
- 経路特異的な断絶とヴォクセル特異的な断絶マップは,認知機能との関連を分析するために生成されました.
主要な成果:
- 認知機能は,MSコホートで評価されたすべての領域で低下した (p < 0. 001).
- 断裂体積は認知能力を有意に予測した (β = -0.41,p = 0.004),決定因子として病変体積を上回る.
- 特定の白質管は,SDMTの左帯状後部,CVLT-IIの左帯状後部,BVMT-Rの右帯状後部と関連付けられました.
結論:
- 病変による脱線は 病変の負担よりもMSに関連する認知障害の 重要な要因です
- 統合失調症の認知欠陥の根底にあるネットワークレベルのメカニズムを理解するための貴重なアプローチです.
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