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Updated: Sep 9, 2025

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SPI1によるFARSBのダウンレギュレーションは,mTOR経路を通じて肺腺がんの進行と免疫微環境を調節する

Yiting Wang1, Yifan Zhou2, Shangwei Chen2

  • 1Laboratory Medical, Guangxi Hospital Division of The First Affiliated Hospital, Sun Yat-sen University, Guangxi, China.

Journal of the Chinese Medical Association : JCMA
|September 3, 2025
PubMed
まとめ

転写因子SPI1は,肺腺がん (LUAD) のフェニララニル- tRNA合成酵素サブユニット (FARSB) を抑制する. この抑制は腫瘍の進行を阻害し,mTOR経路を遮断することによって抗腫瘍免疫を強化します.

キーワード:
FARSB免疫ミクロ環境肺腺がんSPI1 についてmTOR信号経路について

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