Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

T Cell Types and Functions01:24

T Cell Types and Functions

1.4K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.4K
Autoimmune Disorders01:29

Autoimmune Disorders

667
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
667

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Tetraploidy in cancer: Diagnostic and therapeutic perspectives.

Biochemical pharmacology·2026
Same author

An electrophysiological and proteomics roadmap for human induced glutamatergic neurons: fine-tuning of culture conditions for pathophysiological studies.

Cell death discovery·2026
Same author

Effectiveness of nirsevimab immunisation after birth versus RSVpreF maternal vaccination in preventing RSV-related hospitalisations in infants: a population-based retrospective cohort study.

The Lancet. Child & adolescent health·2026
Same author

FOXJ1 transcriptional targets in human airway cells and impaired multiciliogenesis in FOXJ1-associated primary ciliary dyskinesia.

American journal of respiratory cell and molecular biology·2026
Same author

Differential diagnosis within primary molar retention: Characteristics of primary eruption failure versus primary retention of a single tooth

L' Orthodontie francaise·2026
Same author

CD19 expression associates with polyfunctionality and altered secretion dynamics in individual activated human B cells.

Journal of immunology (Baltimore, Md. : 1950)·2026
Same journal

Fast Generation of F(Ab')<sub>2</sub> Fragments From Human IgG Using Fc-Fused IgG-Degrading Enzyme.

European journal of immunology·2026
Same journal

Generation of Regulatory T Cells Against Islet Neoantigen.

European journal of immunology·2026
Same journal

Complement Inhibition in the Clinic: Are We Doing Enough to Protect Patients From Infection?

European journal of immunology·2026
Same journal

Special Issue: yEFIS 3rd Symposium.

European journal of immunology·2026
Same journal

CRISPR/Cas9-Mediated Gene Knockout Reveals a Nonredundant Role for p16<sup>INK4A</sup> in Controlling TCR-Dependent and Independent CD8 T Cell Expansion.

European journal of immunology·2026
Same journal

Induction of Humoral and Cellular Immunity After SARS-CoV-2 JN.1 Vaccination in Individuals With and Without Prior Infection.

European journal of immunology·2026
関連記事をすべて見る

関連する実験動画

Updated: Sep 9, 2025

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry
12:36

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

Published on: June 26, 2018

9.6K

系統性自己炎症疾患の患者と健康な対照群の間の多機能性における単細胞差

Aline Linder1, Farah Diab2, Loïc de Pontual3

  • 1Laboratory For Functional Immune Repertoire Analysis, Department of Chemistry and Applied Biosciences, ETH Zurich, Zurich, Switzerland.

European journal of immunology
|September 3, 2025
PubMed
まとめ
この要約は機械生成です。

系統的自己炎症疾患は,異常なサイトカインの放出を含む. この研究では,患者のサイトカイン分泌と細胞機能を測定し,健康な個人に比べて自然免疫反応の変化を明らかにしました.

さらに関連する動画

Accurate and Simple Measurement of the Pro-inflammatory Cytokine IL-1&#946; using a Whole Blood Stimulation Assay
06:29

Accurate and Simple Measurement of the Pro-inflammatory Cytokine IL-1β using a Whole Blood Stimulation Assay

Published on: March 1, 2011

26.5K
Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts
08:51

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts

Published on: September 20, 2024

1.5K

関連する実験動画

Last Updated: Sep 9, 2025

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry
12:36

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

Published on: June 26, 2018

9.6K
Accurate and Simple Measurement of the Pro-inflammatory Cytokine IL-1&#946; using a Whole Blood Stimulation Assay
06:29

Accurate and Simple Measurement of the Pro-inflammatory Cytokine IL-1β using a Whole Blood Stimulation Assay

Published on: March 1, 2011

26.5K
Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts
08:51

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts

Published on: September 20, 2024

1.5K

科学分野:

  • 免疫学
  • 分子生物学
  • 遺伝学

背景:

  • 系統的自己炎症性疾患 (SAID) は,シトカインの分泌とシグナル伝達が調節不能であることが特徴です.
  • SAIDにおける免疫機能の制御不全の正確なメカニズムを理解することは,効果的な治療法の開発に不可欠です.

研究 の 目的:

  • SAID患者における免疫不調を特徴づけるために
  • シングル・セルレベルでの サイトカイン分泌のプロフィール
  • 分泌ダイナミクスと細胞の多機能性を測定する.

主な方法:

  • SAID患者と健康な対照群の免疫細胞の単細胞サイトカインプロファイリング.
  • サイトカイン分泌の動態の定量分析
  • 細胞の多機能性の評価

主要な成果:

  • 健康な対照群と比較して,SAID患者における異なるサイトカイン分泌パターンを特定した.
  • 分泌ダイナミクスと細胞の多機能性における量化された差異
  • ドナーの間の免疫反応の自然な変動を明らかにした.

結論:

  • シングル・セル・サイトカイン・プロフィーリングは,SAIDにおける免疫不調に関する貴重な洞察を提供します.
  • 個々の免疫反応の変動性を理解することは,SAIDにおけるパーソナライズド・メディカル・アプローチに不可欠です.