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Updated: Sep 9, 2025

Author Spotlight: Advancing Therapeutics to Treat Vibriosis in Humans and Aquatic Organisms
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フォルモスルファチアゾール:構造的見直し

Claudio Maestri1,2, Toni Grell3, Fabio Travagin1

  • 1Dipartimento di Scienze del Farmaco, Università del Piemonte Orientale, Largo Guido Donegani 2, Novara (NO), 28100, Italy.

ChemPlusChem
|September 3, 2025
PubMed
まとめ

バクテリア感染症に使用される前薬であるFormosulfathiazole (FSTz) は,以前考えられていたように定義されていないポリマーではなく,明確に定義されたサイクロファンの構造を持つことが判明しました. この発見により この重要な薬剤の成分に対する理解が 修正されました

キーワード:
サイクロディマーサイクロファン電子 difraktion 電子 difraktion 電子 difraktion についてフォーモスルファチアゾール構造改革について

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Sulfides are the sulfur analog of ethers, just as thiols are the sulfur analog of alcohol. Like ethers, sulfides also consist of two hydrocarbon groups bonded to the central sulfur atom. Depending upon the type of groups present, sulfides can be symmetrical or asymmetrical. Symmetrical sulfides can be prepared via an SN2 reaction between 2 equivalents of an alkyl halide and one equivalent of sodium sulfide.
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Thiols and sulfides are sulfur analogs of alcohols and ethers, respectively, where the sulfur atom takes the place of the oxygen atom. Thus, thiols are generally represented as RSH, where R is an alkyl substituent and —SH is the functional group. On the other hand, in sulfides, the central sulfur atom is bonded to two hydrocarbon groups on either side. Depending upon the type of group, sulfides can be either symmetrical or asymmetrical. Both thiols and sulfides display a bent geometry,...
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Nitrous acid, a weak acid, is prepared in situ via the reaction of sodium nitrite with a strong acid under cold conditions. This nitrous acid prepared in situ reacts with primary arylamines to form arenediazonium salts. Such reactions are known as diazotization reactions. As shown in Figure 1, the formation of arenediazonium salts begins with the decomposition of nitrous acid in an acidic solution to give nitrosonium ions.
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