関連する実験動画
Updated: Sep 9, 2025

08:02
Phospholipid Mediator Induced Transformation in Three-Dimensional Cultures
Published on: July 27, 2022
2.6K
高脂肪食は,PLATシグナル伝達を通じてCAFと免疫細胞の相互作用を調節することによって,乳がんの進行に影響する
Weihan Li1, Jiangshan He2,3, Jingjing Li4
1Department of Acupuncture and Moxibustion, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, PR China.
The Journal of pathology
|September 3, 2025
まとめ
脂肪が多い食事は 腫瘍の微小環境の相互作用を変えることで 乳がんを助長します 癌に関連した線維細胞は,特にPLATシグナル伝達によって,免疫細胞に影響を与え,疾患の進行を加速します.
科学分野:
- 腫瘍学
- 免疫学
- メタボリズム
背景:
- 腫瘍の微小環境 (TME) の相互作用は,特にがんに関連した線維細胞 (CAF) と免疫細胞の相互作用は,乳がんの進行を決定的に影響する.
- 高脂肪食 (HFD) などの食事の要因は,TMEと癌の発生に大きく影響する.
研究 の 目的:
- CAFがHFD条件下でTME内の免疫細胞を調節する方法を調査する.
- 免疫細胞の行動と乳がんの進行と患者の結果との関連性を影響するCAFの鍵となる遺伝子を特定する.
主な方法:
- 乳がん患者からの単細胞および大量RNAシーケンシングデータ (TCGA-BRCA,GEOデータセット) の分析.
- CAFと免疫細胞の相互作用と遺伝子発現を評価するために,マウンの体内のモデルと体内の細胞培養実験.
- 患者の生存率,免疫細胞の浸透,および臨床的特徴との候補遺伝子の相関分析.
主要な成果:
- HFDは,CAF- 免疫細胞の伝達が変化し,乳がん患者におけるストロマおよび免疫スコアが低下した.
- CAFマーカー遺伝子PLATは,免疫細胞の浸透に関連した重要な要素として特定されました.
- HFDは腫瘍に関連したマクロファージの浸透を促進し,体内でCD4+T細胞の活性化を阻害した.
- PLAT発現の減少はM2マクロファージの偏分化を促進し,がん細胞の侵入と移動をインビトロで強化した.
結論:
- HFDはCAFと免疫細胞の相互作用を調節し,潜在的に進行を加速することによって,乳がんTMEを再構成します.
- PLATシグナリングは,HFD誘発の乳がんにおける重要な媒介体として現れ,免疫細胞の浸透とマクロファージの偏化に影響を与える.
- CAF-免疫細胞のクロストラック,特にPLATシグナリングをターゲットにすることで,HFDに関連した乳がんの治療戦略を提供することができる.
関連する概念動画
mTOR Signaling and Cancer Progression
3.9K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.9K
Cancer Prevention
6.3K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.3K
PI3K/mTOR/AKT Signaling Pathway
3.9K
The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast, mTORC2 consists of a...
3.9K
Interactions Between Signaling Pathways
6.4K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
6.4K
Inhibition of Cdk Activity
4.9K
The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
4.9K

