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Updated: Sep 9, 2025

An In Ovo Model for Testing Insulin-mimetic Compounds
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2型糖尿病への介入のためのα-アミラーゼとα-グルコシダゼを標的とする二重酵素阻害剤としての1,2,3-トリアゾールの開発

K Sruthi1, S L Manju1

  • 1Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore, India.

Archiv der Pharmazie
|September 3, 2025
PubMed
まとめ

新しい1,2,3-トリアゾール誘導体は,重要な炭水化物を水解する酵素を阻害することで,2型糖尿病の管理に有望である. 化合物6aは強力なα-グルコシダース阻害を示し,6hは強力なα-アミラーゼ阻害を示し,治療の可能性を示唆した.

キーワード:
1,2,3-トリアゾールADME についてMTT測定法抗酸化物質分子ドッキングα-グルコシダゼとα-アミラーゼの抑制

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