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Updated: Sep 9, 2025

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
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抗がん剤としてのp53-MDM2相互作用を標的とするフロピリミジン-ピラゾール混合化合物の発見

Mai A Mansour1, Ghaneya S Hassan1,2, Maiy Y Jaballah3

  • 1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Badr University in Cairo, Badr City, Cairo, Egypt.

Archiv der Pharmazie
|September 3, 2025
PubMed
まとめ

研究者は,p53-MDM2の相互作用を阻害する新しいピラゾリン化合物を開発し,潜在的な抗がん療法のために腫瘍抑制 p53の機能を回復しました. 化合物6dは,癌細胞に対する有意な抗増殖活性と選択性を示した.

キーワード:
MDM2阻害X線微分法抗がん作用p53とMDM2の相互作用合成野生型p53

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