その 価値 が ある か 化学予防試験の米国および国際参加者 > 650 人からの応答データ
David Zahrieh1, Carrie A Strand2, Paul J Limburg3
1Mayo Clinic, Rochester, United States.
Cancer prevention research (Philadelphia, Pa.)
|September 3, 2025
まとめ
早期化学予防試験における参加者の満足度は全体的に高かった (85%). しかし,黒人/アジア人/人種と有害事象や早期終了を経験した参加者は満足度が低いと報告し,改善すべき領域を強調した.
科学分野:
- 臨床試験
- 癌 予防 研究
- 患者による報告結果
背景:
- 早期の化学予防試験は新しいがん予防戦略の開発に不可欠です
- 参加者の満足度を理解することは 試験の累積,留守,遵守を改善するために不可欠です.
- これまでの研究は,この特定の試験環境における満足度要因を 詳しく調べていなかった.
研究 の 目的:
- 早期化学予防試験における参加者の満足度を評価する.
- 参加者の満足度に関連した 人口統計学的および試験関連の要因を特定する.
主な方法:
- 癌予防ネットワークの13の早期化学予防試験 (2006年-2021年) のデータの分析
- 5項目の"その価値はあったか?"の管理 全体の満足度を評価するアンケートです.
- 652人の参加者の全体的な満足度の予測要因を特定するための統計的分析
主要な成果:
- 全体の満足度は85%だった.
- 白人,非ヒスパニック/ラテン系参加者と比較して,黒人/アジア人/>1種の民族性 (OR2. 96,P<0. 001) と著しく低い満足度であった.
- 不満足度の増加は,介入前の有害事象 (OR1. 9 , P=0. 012),介入中の長期間の有害事象 (OR1. 8 , P=0. 024),早期の試験終了 (OR7. 4 , P< 0. 001) と関連していた.
結論:
- 全体的な満足度は高いものの,特定のサブグループや経験は,化学予防試験における参加者の満足度に悪影響を及ぼします.
- 結果は,被験者の体験を改善するために有害事象と試験期間に対処する必要性を示唆しています.
- 満足度の向上により 将来の臨床試験の累積率,受験者の留守率,従順度,がん予防研究の多様性が向上します
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