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cBioPortalシステムの拡張は,シュレズヴィヒ・ホルシュタイン大学病院のサイト中心の臨床試験検索を含みます
Anke Neumann1, Torge Ablaß1,2, Ann-Kristin Kock-Schoppenhauer1,2
1Institute of Medical Biometry and Statistics, Section for Clinical Research-IT, University of Luebeck and University Hospital Schleswig-Holstein, Lübeck, Germany.
Studies in health technology and informatics
|September 3, 2025
まとめ
シュレズヴィヒ・ホルシュタイン大学病院 (UKSH) の分子腫瘍委員会では,患者の臨床試験へのアクセスを改善する新しい検索機能が開発されました. このシステムは,適切な腫瘍学研究を効果的に特定し,治療の推奨を行います.
科学分野:
- 生物医学情報学
- 臨床研究情報学
- 腫瘍学
背景:
- シュレズヴィヒ・ホルシュタイン大学病院 (UKSH) でのサイト中心の臨床試験の実施.
- 分子腫瘍委員会の 治療上の勧告を 支持することに重点を置く
研究 の 目的:
- 効果的な臨床試験の検索機能を開発し,統合する.
- 患者に関連する腫瘍学研究へのアクセスを改善する.
主な方法:
- 地元の臨床試験の主要なデータ源としてUKSH研究レジストリを使用した.
- 中間データ形式としてFast Healthcare Interoperability Resources (FHIR) を採用した.
- cBioPortalソフトウェアを,統合された検索機能のためのカスタム型スクリプトで拡張しました.
主要な成果:
- 抽出・変換・負荷 (ETL) プロセスを確立し,FHIRに適合する研究レジストリを作成しました.
- 研究データをFHIR R4リソースに変換し,医療情報工学イニシアチブの基準を遵守しました.
- cBioPortalの患者インターフェイスに新しい研究検索機能が統合され,パラメータを定義するダイアログボックスが搭載されています.
結論:
- 実施された検索機能は,UKSH FHIR研究登録データを有効に活用して,適切な臨床試験を特定します.
- このBioPortalの拡張機能は,がん研究を効率的に検索することを容易にする.
- このシステムは 分子腫瘍委員会が 治療法を推奨する能力を高め 臨床試験への患者登録を改善します
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