関連する実験動画

Updated: Sep 9, 2025

Inducible and Reversible Dominant-negative DN Protein Inhibition
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液体コンデンサートにおけるRBM10抑制されたRORB活性をターゲットにすることで,NF-κBシグナル伝達に影響を及ぼすことにより,ライソソーム生物形成と神経芽細胞腫の進行を抑制する

Yanhua Guo1, Xiaojing Wang1,2, Chunhui Yang1

  • 1Department of Pediatric Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, Hubei Province, 430022, P. R. China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|September 3, 2025
PubMed
まとめ

RARに関連する孤児受容体B (RORB) は,NF- kBシグナル伝達とリソソームバイオゲネシスを抑制することによって,神経芽細胞腫 (NB) の成長を抑制する. RBM10- RORBの相互作用をターゲットにすることで,NBの治療戦略が提供されます.

キーワード:
RARに関連する孤児受容体BRNA結合モチーフタンパク質 10リソームバイオゲネシス神経芽細胞腫核因子カッパB

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