Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

E1 Reaction: Kinetics and Mechanism02:46

E1 Reaction: Kinetics and Mechanism

15.7K
Here, in contrast to the E2 reaction mechanism, we delve into the aspects of the E1 reaction mechanism, which has two steps: rate-limiting loss of the leaving group and abstraction of the beta hydrogen by a weak base. Typically, the experimental proof for the E1 mechanism is via kinetic studies or isotope studies. While the former demonstrates the first-order kinetics—the dependence of the reaction solely on substrate concentration—the latter proves the abstraction of hydrogen only...
15.7K
Radical Chain-Growth Polymerization: Overview01:10

Radical Chain-Growth Polymerization: Overview

2.7K
Chain-growth or addition polymerization is successive addition reactions of monomers with a polymer chain. In radical chain-growth polymerization, the reaction proceeds via a free-radical intermediate. The free radical is formed from radical initiators, which spontaneously generate free radicals by homolytic fission. Organic peroxides (such as dibenzoyl peroxide, as shown in Figure 1) or azo compounds are popular radical initiators. A low concentration ratio of radical initiator to monomer is...
2.7K
E2 Reaction: Kinetics and Mechanism02:45

E2 Reaction: Kinetics and Mechanism

10.6K
SN2 substitutions and E2 eliminations of alkyl halides proceed via a concerted pathway. While the nucleophile attacks the alpha carbon in SN2 reactions, it functions as a strong base and abstracts a beta hydrogen in the E2 mechanism. The rate-limiting transition state in E2 elimination reactions is characterized by partially broken carbon–hydrogen and carbon–halogen bonds and a partially formed pi bond between the alpha and beta carbons. The beta hydrogen and halide are eliminated...
10.6K
Radical Chain-Growth Polymerization: Mechanism01:09

Radical Chain-Growth Polymerization: Mechanism

2.8K
The radical chain-growth polymerization mechanism consists of three steps: initiation, propagation, and termination of polymerization. The polymerization initiates when a free radical generated from the radical initiator adds to the unsaturated bond in the monomer. The unpaired electron of the free radical and one π electron in the unsaturated bond creates a σ bond between the free radical and the monomer. As a result, the other π electron in the unsaturated bond converts this...
2.8K
What is Organic Chemistry?02:17

What is Organic Chemistry?

80.0K
Organic chemistry is the study of compounds of carbon called organic compounds. Organic compounds either originate from living organisms or are synthesized by chemists. A defining trait of these compounds is the presence of carbon as the principal element, which is bonded to other carbon atoms and other elements such as hydrogen, oxygen, nitrogen, and sulfur. The existence of a wide array of organic molecules is a consequence of carbon atoms’ ability to form up to four strong bonds to...
80.0K
SN2 Reaction: Kinetics02:14

SN2 Reaction: Kinetics

8.7K
Kinetic Studies and Significance
In a chemical reaction, a relationship exists between the concentration of reactants and the rate at which the reaction proceeds. The study to measure this relationship is known as the kinetics of a chemical reaction. Kinetic studies are used to deduce the rate law of a chemical reaction, which provides information about the species involved during the transition state of the rate-determining step. Thus, kinetic studies help to derive the mechanism of a...
8.7K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Accelerating Photochemical Insight with "Roblonski", a Robo-Fluidic Platform.

ACS central science·2026
Same author

Flash Communication: Probing Fe Complex Assembly via Thermogravimetric Analysis.

Organometallics·2026
Same author

Decarboxylative Cross-Coupling Enabled by Fe and Ni Metallaphotoredox Catalysis.

Journal of the American Chemical Society·2024
Same author

Multimetallic-Catalyzed C-C Bond-Forming Reactions: From Serendipity to Strategy.

Journal of the American Chemical Society·2023

関連する実験動画

Updated: Sep 9, 2025

Author Spotlight: Accelerating Discovery in Microporous Material Chemistry
07:20

Author Spotlight: Accelerating Discovery in Microporous Material Chemistry

Published on: October 6, 2023

3.7K

高通量実験を用いた有機化学の進歩

Reem Nsouli1, Gaurav Galiyan2, Laura K G Ackerman-Biegasiewicz1

  • 1Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, GA, 30322, USA.

Angewandte Chemie (International ed. in English)
|September 3, 2025
PubMed
まとめ

高通量実験 (HTE) は,反応とデータ収集を最適化することで,有機合成と機械学習を加速します. 自動化,AI,データ管理の進歩は,より広範なイノベーションのためのHTEの課題を克服しています.

キーワード:
化学情報学組み合わせ化学高通量スクリーニング合成設計合成方法

さらに関連する動画

Optimization of the Ugi Reaction Using Parallel Synthesis and Automated Liquid Handling
08:24

Optimization of the Ugi Reaction Using Parallel Synthesis and Automated Liquid Handling

Published on: November 11, 2008

16.5K
Optimizing the Use of a Liquid Handling Robot to Conduct a High Throughput Forward Chemical Genetics Screen of Arabidopsis thaliana
11:58

Optimizing the Use of a Liquid Handling Robot to Conduct a High Throughput Forward Chemical Genetics Screen of Arabidopsis thaliana

Published on: April 30, 2018

6.8K

関連する実験動画

Last Updated: Sep 9, 2025

Author Spotlight: Accelerating Discovery in Microporous Material Chemistry
07:20

Author Spotlight: Accelerating Discovery in Microporous Material Chemistry

Published on: October 6, 2023

3.7K
Optimization of the Ugi Reaction Using Parallel Synthesis and Automated Liquid Handling
08:24

Optimization of the Ugi Reaction Using Parallel Synthesis and Automated Liquid Handling

Published on: November 11, 2008

16.5K
Optimizing the Use of a Liquid Handling Robot to Conduct a High Throughput Forward Chemical Genetics Screen of Arabidopsis thaliana
11:58

Optimizing the Use of a Liquid Handling Robot to Conduct a High Throughput Forward Chemical Genetics Screen of Arabidopsis thaliana

Published on: April 30, 2018

6.8K

科学分野:

  • 有機化学
  • 化学工学
  • データサイエンス

背景:

  • 高通量実験 (HTE) は,化合物ライブラリを生成し,反応を最適化するために不可欠です.
  • 有機合成のためのHTEの課題には,多様な作業流と反応剤の要求が含まれています.
  • 機械学習 (ML) アプリケーションはHTEデータ収集から利益を得ます.

研究 の 目的:

  • 有機合成のための高通量実験 (HTE) ワークフローの最近の進歩をレビューする.
  • 自動化,人工知能 (AI),HTEにおけるデータ管理の改善を強調する.
  • 有機合成におけるHTEの現在の課題と将来の方向性を検討する.

主な方法:

  • 最近の文献とHTEの技術的進歩のレビュー
  • プロトコルの標準化,再現性の向上,効率性の向上のための戦略の分析.
  • アクセシビリティと共有性に関するデータ管理の検討

主要な成果:

  • HTEのワークフローでは,反応設計,実行,分析,データ管理の進歩が見られました.
  • 自動化,AI,カスタマイズされたワークフローはHTEにおける再現性と効率性を高めます.
  • データ管理の改善により,HTEデータへのアクセシビリティと共有性が向上します.

結論:

  • HTEは有機合成におけるイノベーションを加速させる強力なツールです.
  • テクノロジーを活用して課題に取り組むことは,HTEのインパクトの鍵です.
  • 統合された柔軟で民主化されたプラットフォームとしてHTEを確立することを目指しています.