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Updated: Sep 9, 2025

Pancreatic Tissue-Derived Extracellular Matrix Bioink for Printing 3D Cell-Laden Pancreatic Tissue Constructs
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アミリン集積における細胞外マトリクスの役割: 2型糖尿病における治療の改善の可能性

Sagarika Prabhakar1, Priyadarshini Veerabhadraswamy1, Nikhil R Gandasi1,2

  • 1Cell Metabolism Lab (GA-08), Department of Developmental Biology and Genetics (DBG), Indian Institute of Science (IISc), Bengaluru 560012, India.

Journal of biosciences
|September 3, 2025
PubMed
まとめ

2型糖尿病 (T2DM) のアミリン集積はベータ細胞死亡とインスリン分泌の障害を引き起こす. このペプチドは通常溶解性だが,ストレス下では有毒なアミロイド線維を形成する.

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