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Updated: Sep 9, 2025
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Basophil Activation Test for Allergy Diagnosis
Published on: May 31, 2021
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慢性ヒスタミナージック血管腫と慢性疹と血管腫の人口統計学的および臨床的特徴,マルチセンターのイタリアでの経験
S Sartorio1, F Rivolta2, A Tedeschi3
1Allergology and Clinical Immunology Residency, University of Milan, Milan, Italy.
European annals of allergy and clinical immunology
|September 3, 2025
まとめ
慢性自発性疹 (CSU) の患者では,疹と血管腫 (AE- CSU) の両方とも,血管腫のみの患者と比較して,アトピーと甲状腺機能低下の割合が高くなります. AE-CSUはまた,より頻繁に発作し,舌の関与が少なくなります.
科学分野:
- アレルギーと免疫学
- 皮膚科
- 内科 医学
背景:
- 慢性自発性疹 (CSU) は,6週間以上続く再発性疹および/または血管腫を引き起こす状態です.
- 亜型にはAE- CSU (ホイールと血管腫) とCHA (慢性ヒスタミナージック血管腫,血管腫のみ) が含まれる.
- CHAとAE- CSU患者の比較データは限られている.
研究 の 目的:
- CHAとAE- CSUの患者の人口統計的および臨床的特徴を分析し,比較する.
- この2つのCSUサブタイプを区別する潜在的な要因を特定する.
主な方法:
- 8つのイタリアのアレルギーセンターで多センター,観察,遡及研究が行われました.
- 44人のCHAと34人のAE- CSU患者 (小児および成人) のデータを分析した.
- 変数には,人口統計,併発性疾患,炎症マーカー,血液検査,薬物使用,血管腫の発作部位,治療法,および12ヶ月の発作頻度が含まれていた.
主要な成果:
- AE- CSU患者では,CHA患者と比較して,アトピー率が高く (58. 8% vs 29. 5%) 甲状腺機能低下と甲状腺抗体がより頻繁に検出されました.
- 両方において顔が共通した攻撃部位であったが,CHAでは舌の血管腫がより一般的であった (22. 7%対2. 9%).
- CHAの上部呼吸道への関与は主に男性で観察され,AE- CSUの患者は診断時に毎月の発作頻度が高くなった (2. 1対1. 45).
結論:
- 人口統計学的および臨床的要因は,AE-CSUとCHAを区別することができる.
- AE- CSUは,アトピー,甲状腺機能低下,甲状腺抗体の増加,および発作の頻度の上昇と関連しています.
- CHA患者は舌の血管腫に罹患し,男性では上部呼吸道に感染する傾向があります.
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