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Updated: Sep 9, 2025

Methods to Study Lipid Alterations in Neutrophils and the Subsequent Formation of Neutrophil Extracellular Traps
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Methods to Study Lipid Alterations in Neutrophils and the Subsequent Formation of Neutrophil Extracellular Traps

Published on: March 29, 2017

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PIM1は,コレステロール代謝経由でCD4+ T細胞の炎症的不均衡を調整する

Mei Liu1,2,3, Jia-Qi Wang1,2,3,4, Jia-Ning Wang1,2,3,4

  • 1National Clinical Research Center for Laboratory Medicine, The First Hospital of China Medical University, Shenyang, China.

mBio
|September 3, 2025
PubMed
まとめ

モローニーマウリン白血病ウイルス1 (PIM1) のプロウィルス統合部位は,セプシス中のCD4+T細胞で上位調節され,免疫不均衡を引き起こします. PIM1は,コレステロール代謝を通じてTh1,Th17,Treg細胞のバランスを調節し,敗血症の治療対象となる.

キーワード:
CD4+ T細胞PIM1 についてコレステロール代謝炎症セプシス

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Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis05:28

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