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Updated: Sep 9, 2025

Chemical Dimerization-Induced Protein Condensates on Telomeres
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テロメアSUMOレベルはAPB形成経路とALT効率の選択に影響する

Rongwei Zhao1, Xiaoyang Yu1, Tafadzwa Chigumira1

  • 1Department of Biology, Carnegie Mellon University, Pittsburgh, PA, USA.

The Journal of cell biology
|September 3, 2025
PubMed
まとめ

テロメアの代替延長 (ALT) 経路の癌は,新規核形成または融合によって,ALT関連PML体 (APB) を形成する. 高濃度のSUMOはAPBの核形成を促進し,テロメアの維持のためにALTの活性を増強する.

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