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Updated: Sep 9, 2025

Author Spotlight: THP-1 Macrophage Response to LPS/ATP — Unveiling the Pyroptosis, Apoptosis, and Necroptosis Spectrum
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Author Spotlight: THP-1 Macrophage Response to LPS/ATP — Unveiling the Pyroptosis, Apoptosis, and Necroptosis Spectrum

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プログラム さ れ た 細胞 死亡 を 制御 する ため の エラスティン の よう な ポリペプチド を 使う 熱 生成 ツール

Cong Quang Vu1, Satoshi Arai1

  • 1WPI Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, Kanazawa 920-1192, Japan.

ACS nano
|September 3, 2025
PubMed
まとめ

熱遺伝学では 熱で活性化されたタンパク質を使って 精密な細胞制御を可能にします 研究者は,カスパース8 (CASP8) と融合した温度反応性エラスティン型ポリペプチド (ELP) を使用して,熱誘導性プログラム細胞死システムを開発した.

キーワード:
フリムカスパース 8エラスティンのようなポリペプチド光学的な加熱プログラムされた細胞死熱遺伝学

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Apoptosis is a combination of two Greek words, 'apo' and 'ptosis,' meaning separation and falling off, respectively. Hippocrates used this word to describe gangrene, which was caused due to bandaging of fractured bones. Apoptosis was distinguished from necrosis in 1970 when John Kerr reported observations of morphological changes occurring during apoptosis. During one experiment, he observed that the disruption of blood supply to the liver tissue resulted in a size...
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