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Updated: Sep 9, 2025

In vitro Organoid Culture of Primary Mouse Colon Tumors
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サイトレート合成スプライス・ヴァリエントは,TCAサイクルをリワイヤして結腸癌の進行を促進する

Justin Chak Ting Cheung1, Lok Wan Ng2, Zhongxu Zhu3

  • 1Chinese University of Hong Kong, Hong Kong, Hong Kong.

Cancer research
|September 3, 2025
PubMed
まとめ

新しく発見されたシトラート合成酵素 (CS) スプライシング変種であるCS-ΔEx4は,トリカルボキシル酸 (TCA) サイクルを変化させることで結腸直腸がん (CRC) の進行を促します. この変種を標的とした治療は CRC 治療において有望である.

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