Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Calmodulin-dependent Signaling01:16

Calmodulin-dependent Signaling

5.3K
Calmodulin (CaM) is a calcium-binding protein in eukaryotes that controls various calcium-regulated cellular processes. It has four calcium-binding sites that bind calcium to form the calcium-calmodulin ( Ca2+-CaM) complex. GPCR stimulation increases the calcium levels in the cells that bind to CaM and induces a conformational change.
The Ca2+-CaM complex does not have enzymatic activity by itself. Instead, the complex binds downstream target proteins, including membrane proteins or enzymes,...
5.3K
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

57
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
57
Rheumatic Heart Disease III: Medical Management01:21

Rheumatic Heart Disease III: Medical Management

31
Rheumatic heart disease (RHD) management can be divided into two main strategies: prevention and long-term management.Primary PreventionPrimary prevention focuses on timely diagnosis and management of group A streptococcal pharyngitis to prevent acute rheumatic fever. The most widely used antibiotic for treating this condition is intramuscular benzathine penicillin G.Acute Rheumatic Fever TreatmentThe primary treatment goal for a patient diagnosed with acute rheumatic fever is to suppress the...
31
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

38
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
38
cAMP-dependent Protein Kinase Pathways01:25

cAMP-dependent Protein Kinase Pathways

6.6K
Cyclic Adenosine Monophosphate (cAMP) is an essential second messenger that activates protein kinase A (PKA) and regulates various biological processes. A single epinephrine molecule binds to GPCR and activates several heterotrimeric G proteins, each stimulating multiple adenylyl cyclase, amplifying the signal, and synthesizing large numbers of cAMP molecules. Small changes in cAMP concentration affect PKA activity. The binding of four cAMP molecules induces a conformational change in PKA,...
6.6K
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

34
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
34

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Natural History of Asymptomatic Phenotypically Mild HCM: Insights From the SHaRe Registry.

Journal of the American College of Cardiology·2026
Same author

Catheter ablation of atrial fibrillation in transthyretin and light-chain cardiac amyloidosis: results from the multicentre AMYL-AF study.

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology·2026
Same author

Invasive exercise hemodynamics in obstructive and non-obstructive hypertrophic cardiomyopathy.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same author

How Many CPVT Patients Need an ICD?: The Impact of Left Cardiac Sympathetic Denervation.

JACC. Clinical electrophysiology·2026
Same author

Machine learning-guided risk stratification for long QT syndrome genetic variants with hiPSC-derived cardiomyocytes.

Cardiovascular research·2026
Same author

MTMR4 variants have opposite gene-specific impact on life-threatening arrhythmic risk in type 1 and 2 long QT syndrome.

European heart journal·2026

関連する実験動画

Updated: Sep 9, 2025

Pull-down of Calmodulin-binding Proteins
07:51

Pull-down of Calmodulin-binding Proteins

Published on: January 23, 2012

25.4K

カルモジュリノパシー: レジストリの必要性

Peter J Schwartz1, Lia Crotti2

  • 1Istituto Auxologico Italiano IRCCS, Center for Cardiac Arrhythmias of Genetic Origin and Laboratory of Cardiovascular Genetics, Milano, Italy.

JACC. Clinical electrophysiology
|September 3, 2025
PubMed
まとめ

カルモジュリノパシーとは 心臓発作による突然死につながる 珍しい遺伝疾患です 患者の国際カルモジュリノパシー登録は 病気のメカニズムを理解し 患者の管理を改善するために不可欠です

さらに関連する動画

Monitoring Endoplasmic Reticulum Calcium Homeostasis Using a Gaussia Luciferase SERCaMP
08:41

Monitoring Endoplasmic Reticulum Calcium Homeostasis Using a Gaussia Luciferase SERCaMP

Published on: September 6, 2015

13.3K
Dual-Dye Optical Mapping of Hearts from RyR2R2474S Knock-In Mice of Catecholaminergic Polymorphic Ventricular Tachycardia
09:36

Dual-Dye Optical Mapping of Hearts from RyR2R2474S Knock-In Mice of Catecholaminergic Polymorphic Ventricular Tachycardia

Published on: December 22, 2023

1.3K

関連する実験動画

Last Updated: Sep 9, 2025

Pull-down of Calmodulin-binding Proteins
07:51

Pull-down of Calmodulin-binding Proteins

Published on: January 23, 2012

25.4K
Monitoring Endoplasmic Reticulum Calcium Homeostasis Using a Gaussia Luciferase SERCaMP
08:41

Monitoring Endoplasmic Reticulum Calcium Homeostasis Using a Gaussia Luciferase SERCaMP

Published on: September 6, 2015

13.3K
Dual-Dye Optical Mapping of Hearts from RyR2R2474S Knock-In Mice of Catecholaminergic Polymorphic Ventricular Tachycardia
09:36

Dual-Dye Optical Mapping of Hearts from RyR2R2474S Knock-In Mice of Catecholaminergic Polymorphic Ventricular Tachycardia

Published on: December 22, 2023

1.3K

科学分野:

  • 心臓病科
  • 遺伝学
  • 分子生物学

背景:

  • カルモジュリノパシーとは,突然の心臓死のリスクが高い 珍しい遺伝疾患です.
  • CALM遺伝子の病気を引き起こす変異は,重度の長QT症候群,カテコアミナージック多型心室動脈不全,およびイディオパシー心室動を引き起こす.
  • 現在の知識は,国際カルモジュリノパシー登録 (ICamR) の限られたデータに依存し,進歩を妨げています.

研究 の 目的:

  • ICamRでの 患者の慢性的な増殖を 解決するためです
  • 孤立した症例を含む患者の登録に世界の医師の参加を要請する.
  • 総合的な遺伝子型-フェノタイプ相関とリスクの階層化を改善するために十分なデータを収集する.

主な方法:

  • ICamRに患者のデータを 提供するよう世界中の医師に呼びかけました
  • 長いQT症候群に対する以前の取り組みからの既存の知識を活用する.
  • 心臓の遺伝疾患の共同レジストリの設立

主要な成果:

  • ICamRの現在の患者数は,科学的な調査には不十分です.
  • 臨床の全スペクトルと遺伝子型とフェノタイプの相関関係を理解する上で重要なギャップが存在します.
  • カルモジュリノパシーの管理を進めるにはデータ収集の改善が不可欠です.

結論:

  • ICamRへの患者登録を急務に必要としています.
  • 病気の症状を定義し,治療戦略を導くには,包括的なデータが不可欠です.
  • カルモジュリノパシーのような稀な心臓病の研究を進めるには 世界的な協力が不可欠です