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Updated: May 5, 2026

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腎臓内髄細胞のヒトマウスアトラスは,狼性腎炎で保存された疾患に関連したマクロファージを特定します

Paul J Hoover1,2, Chirag Raparia3, David J Lieb2

  • 1Division of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

The Journal of experimental medicine
|September 3, 2025
PubMed
まとめ

この研究は,狼性腎炎患者の特定の単細胞とマクロファージのサブセットがマウスモデルに反映されていることを示しています. これらの発見は,マウスモデルを用いて,これらの骨髄性細胞を標的とした新しい炎治療法を開発することを支持しています.

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Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
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