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癌リスク評価 (MICRA) の多次元影響の信頼性と有効性に関するアンケート:日本語版
Tomoko Watanabe1, Kaori Kimura2, Minako Kakimoto3
1Department of Genetic Medicine and Services, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-Ku, Tokyo, 104-0045, Japan.
Familial cancer
|September 3, 2025
まとめ
日本語版の癌リスク評価アンケート (MICRA-J) は,日本における遺伝子検査の心理的社会的影響を評価するための信頼できるツールです. 遺伝性がんリスク評価を受ける人に対する 心理的影響を効果的に測定します
科学分野:
- 心理社会的腫瘍学
- 遺伝子 カウンセリング
- 健康心理学
背景:
- 遺伝性乳がんと卵巣がん (HBOC) の遺伝子検査は 重要な心理的社会的な意味を持つ.
- 多様な集団における遺伝子検査の心理的影響を評価するには 検証されたツールが必要です
- 癌リスク評価の多次元の影響 (MICRA) のアンケートは国際的に使用されています.
研究 の 目的:
- 日本語版のMICRAアンケート (MICRA-J) の作成と検証
- 遺伝子検査の心理社会的影響を評価するためのMICRA-Jの信頼性と有効性を評価する.
- MICRA-Jスコアが BRCA1/2 病原性変異の媒介者と媒介者でない者との間で異なるかどうかを判断する.
主な方法:
- MICRAを日本語に標準化して翻訳し,MICRA-Jを作りました.
- 信頼性 (内部一貫性,再検査) と有効性 (HADSとSF-36v2急性との相関) の評価は,BRCA1/2検査を受けた72人の参加者において行われた.
- BRCA1/2病原性変異のキャリアとBRCA1/2陰性個体間のMICRA- Jスコアの比較.
主要な成果:
- MICRA- Jは良好な内部一貫性 (α > 0. 70) と高いテスト再テスト信頼性 (r = 0. 85) を示した.
- MICRA-Jスコアは,不安/うつ病 (HADS) と正の相関があり,生活の質 (SF-36v2急性) と負の相関がある.
- BRCA1/ 2 病原性変異のキャリアでは,BRCA1/ 2 ネガティブグループと比較して,より高いMICRA- Jスコアが観察されました.
結論:
- MICRA-Jは,日本の集団における遺伝子検査の心理的社会的影響を評価するための信頼できる有効なツールです.
- MICRA-Jは遺伝性がんの遺伝的リスク評価に関連した心理的負担を具体的に測定できます.
- この検証されたツールは,日本で遺伝子検査を受ける個人を心理的に支援するものです.
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