関連する実験動画
Updated: Sep 9, 2025

12:08
Improving IV Insulin Administration in a Community Hospital
Published on: June 11, 2012
19.0K
糖尿病性エウグライセミックケトアシドーシスの管理のためのプロトコルの開発
Zulma Cardona1, Jared G Friedman1, Nevin Kamal1
1Division of Endocrinology, Metabolism, and Molecular Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, 645 N Michigan Ave, Suite 530, Chicago, IL, 60611, USA.
Current diabetes reports
|September 3, 2025
まとめ
SGLT2阻害剤としばしば関連しているエウグリセミック糖尿病性ケトアシドーシス (euDKA) は,特殊な治療を必要とします. 固定インスリンとデクストロースの定位を用いた新しいプロトコルは,従来のDKAプロトコルの限界に対処し,euDKA管理を改善します.
科学分野:
- 内分泌学
- 薬理学について
- 内科 医学
背景:
- 糖尿病性エウグライセミックケトアシドーシス (euDKA) の発生率は,ナトリウム・グルコースコトランスポーター2阻害剤 (SGLT2i) の使用により増加しています.
- 伝統的な糖尿病ケトアシドーシス (DKA) プロトコルは,正常なグルコースレベルのため,euDKAには効果がありません.
- 既存のガイドラインは euDKAの管理について特に言及していません.
研究 の 目的:
- euDKAに関する現在のデータを見直す.
- euDKAの新しい管理プロトコルを導入する.
- SGLT2i薬によるeuDKA治療における課題に対処する.
主な方法:
- euDKA症例と結果の文献レビュー
- 集中治療室での標準化されたeuDKA治療プロトコルの開発と実施
- プロトコルには固定インスリン注入とデクストロースを含む液体の定位が含まれています.
主要な成果:
- euDKA患者は,高血糖DKAと比較して,より長い入院期間と,より遅いアニオンギャップの閉塞を経験します.
- SGLT2iの増加は,euDKAのより高いリスクと相関しています.
- 新しいプロトコルは承認され,現在使用されています.
結論:
- 治療の課題のため,euDKAの標準化されたプロトコルが必要である.
- 開発されたプロトコルは,euDKAの管理に標的を絞ったアプローチを提供します.
- 異なる環境におけるプロトコルの安全性と有効性を評価するには,さらなる研究が必要である.
関連する概念動画
SBAR II: Application of SBAR
4.7K
SBAR is an effective communication tool used by healthcare professionals to communicate patient information accurately. SBAR stands for Situation, Background, Assessment, and Recommendation. For a better understanding, an example is given below.
SBAR Report from a Nurse to a Health Care Provider
S: "Hello, Dr. Smith. This is Jane, RN, from the Med Surg unit. I am calling to tell you about Ms. White in Room 210, who is experiencing increased pain and redness at her incision site. Her recent...
SBAR Report from a Nurse to a Health Care Provider
S: "Hello, Dr. Smith. This is Jane, RN, from the Med Surg unit. I am calling to tell you about Ms. White in Room 210, who is experiencing increased pain and redness at her incision site. Her recent...
4.7K
Hypoglycemia and Glucagon
334
Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
334
Diabetes: Management and Pharmacotherapy
354
The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
354
Diagnosing Acidosis and Alkalosis
512
Diagnosing acid-base imbalances involves systematically analyzing arterial blood samples, focusing on three key measurements: pH, bicarbonate (HCO3−) concentration, and carbon dioxide partial pressure (PCO2). This analysis follows a four-step process that helps identify the imbalance's underlying cause and nature.
First, the pH level is assessed to determine whether the blood pH is normal (7.35–7.45), low (acidosis), or high (alkalosis).
Next, the PCO2 and...
First, the pH level is assessed to determine whether the blood pH is normal (7.35–7.45), low (acidosis), or high (alkalosis).
Next, the PCO2 and...
512
Diabetes Mellitus: Type 2 and Gestational
2.9K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.9K
Insulin: Dosing Regimen and Adverse Effects
253
Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
253

