抗高血圧薬の遵守に関する世界的な研究動向の図鑑分析とマッピング (1975年−2024年)
Mokanpally Sandeep1, M Surya Durga Prasad2, Sree Sudha Tanguturi Yella3
1School of Medical Sciences, University of Hyderabad, Hyderabad, India. 22muph04@uohyd.ac.in.
まとめ
抗高血圧薬の適用に関する世界的な研究は 先進国,特に米国によって支配されています. 低所得国と中所得国における協力と能力構築の強化は,世界的な高血圧の負担に対処するために不可欠です.
科学分野:
- 図書館情報
- 心血管の健康
- 公衆衛生
背景:
- 高血圧は心臓血管疾患の主な危険因子であり,世界中で増加しています.
- 高血圧の管理と生活の質の改善には 薬の服用が不可欠です
- 効果的な介入には 遵守に関する世界的な研究傾向を理解することが不可欠です
研究 の 目的:
- 抗高血圧薬の服用に関する世界的な研究成果と傾向を評価する.
- この研究分野における主要な国,著者,資金源を特定する.
主な方法:
- スコプスデータベースの作成から2024年12月までの資料分析
- VOSViewer,Biblioshiny,QGISをデータ分析に使用した.
- 出版物と資金源,国/著者の貢献,キーワードの同時出現を検証した.
主要な成果:
- 1975年から2024年の間に発行された文書は3497件で,年間成長率は8.65%です.
- 米国 (33%),英国 (8%) とドイツ (7%) が主要な貢献国です.
- シュミッダー・レ 最も多くの論文を出版した 著者であり 血圧高血圧誌はトップの情報源であり NIHは主要な資金提供者です
結論:
- 先進国,特に米国では 抗高血圧薬の投与量に関する研究が主導されています
- 開発途上国からの限られた貢献は,LMICを優先させる必要がある.
- 協調的な研究と能力構築は,文脈特有の証拠を生成し,世界的な高血圧の負担を軽減するために不可欠です.
関連する概念動画
01:28Hypertension IV: Drug Therapy and Lifestyle Modifications
37
Multiple classes of antihypertensive medications are employed in treating hypertension. The most commonly recommended first-line treatments include:Thiazide Diuretics, such as chlorthalidone, increase sodium and water excretion from the body, reducing blood volume and blood pressure.Angiotensin-converting enzyme inhibitors, like lisinopril, block the conversion of angiotensin I to II, a potent vasoconstrictor lowering blood pressure.Angiotensin II Receptor Blockers (ARBs) prevent angiotensin II...
37
01:25Antihypertensive Drugs: Direct Renin Inhibitors
817
The renin-angiotensin-aldosterone system (RAAS) is an intricate physiological pathway involving numerous enzymes and hormones, including renin, angiotensin-converting enzyme (ACE), angiotensin I and II, and aldosterone. Imbalances within this system increase the production of angiotensin II and aldosterone. Increased angiotensin II levels promote vasoconstriction and blood pressure elevation. Concurrently, higher aldosterone levels stimulate sodium and water reabsorption in the kidneys,...
817
01:30Hypertension III: Clinical Manifestations and Diagnostic Studies
48
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
48
01:17Antihypertensive Drugs: Action of β1 Blockers
609
β1-receptors are primarily located in the heart and kidneys. In cardiac myocytes, these receptors interact with neurotransmitters released by the sympathetic nervous system during heightened activity or danger. As a result, β1-receptors get activated, initiating a series of biochemical processes. Excessive activation of beta receptors due to chronic stress can abnormally increase heart rate and contractility, resulting in high blood pressure or hypertension. To counteract this,...
609
01:28Antihypertensive Drugs: Types of β-Blockers
863
β receptors are classified into three subclasses: β1, β2, and β3. β1 receptors are primarily located in the heart and kidneys. When they get activated, they increase heart rate, contractility, and renin release. This process enhances blood pressure and aids in stress management. In contrast, β2 receptors are situated mainly in the lungs, blood vessels, and skeletal muscles. Upon activation, they trigger smooth muscle relaxation, causing bronchodilation and...
863
01:15Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response
123
Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
123