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Updated: Sep 9, 2025

Ischemia-reperfusion Model of Acute Kidney Injury and Post Injury Fibrosis in Mice
09:09

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Published on: August 9, 2013

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アセチル-CoAカルボキシラーゼ阻害剤であるND-630は,アデニン誘発性CKDマウスにおける腎繊維症を予防する

Xinhui Liu1, Yu Peng2,3, Shanshan Wu2,3

  • 1Department of Nephrology, Shenzhen Traditional Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen, 518033, Guangdong, China. liuxinhui0317@163.com.

Naunyn-Schmiedeberg's archives of pharmacology
|September 3, 2025
PubMed
まとめ

ND-630はアセチル-CoAカルボキシラーゼ (ACC) 阻害剤で,慢性腎臓病 (CKD) のマウスモデルで腎臓線維症に対する保護効果を示しています. 線維症,炎症,酸化ストレスを減らすことで腎機能を改善しました.

キーワード:
アセチル-コアカルボキシラーゼ炎症脂質の堆積ND-630 について酸化ストレス腎臓繊維症

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