定期的な運動は,糖尿病のない一般人群において,年齢に関係したイオヘクソールのクリアランスの低下と関連している

Inger T T Enoksen^1,2, Bjørn O Eriksen^1,3, Stein I Hallan^4,5

¹Metabolic and Renal Research Group, UiT - The Arctic University of Norway, Tromsø, Norway.

Clinical journal of the American Society of Nephrology : CJASN

|September 3, 2025

まとめ

定期的な身体活動 (PA) は腎臓機能の低下を遅らせ,慢性腎臓病 (CKD) の加速的な低下のリスクを軽減します. PAの促進は,世界的に増加するCKDの負担と戦うための費用対効果の高い戦略です.

科学分野:

腎臓科
公衆衛生
予防医学

背景:

慢性腎臓病 (CKD) の世界的な流行は,特に高齢者の間で増加しています.
年齢による腎機能低下に対する身体活動 (PA) の影響は十分に確立されていません.

研究の目的:

運動量 (PA) と腎機能の低下率との関連を調査する.
一般人群のコホートでPAと加速した球フィルタレーション率 (GFR) の減少との関係を調べる.

主な方法:

1837人 (RENISコホート) を11年にわたって長期的に研究した.
測定されたGFR (mGFR) は,イオヘクソールのクリアランスを用いて評価され,PAは,運動頻度,強度,期間 (PAFID) のアンケートで評価された.
統計的分析には,線形混合モデルとロジスティック回帰を用いて,GFRの変化と減少リスクに対するPAの影響を評価した.

主要な成果:

PAの頻度が高いと,GFRの加速的な低下の確率は71%減少した.
PAの頻度と年間mGFRの減少の遅さとの間には,用量反応の関係が見られた.
ほぼ毎日PAを患っている人は,mGFRの減少率が0. 47ml/ min/ 1. 73m2/ yearで遅くなりました.

結論:

運動頻度の増加は,腎臓機能の低下を遅らせ,加速した衰退のリスクを低下させる.
定期的な運動を奨励することは慢性腎臓病の世界的な負担を軽減するための重要な低コスト戦略です

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