鉛曝露による血動性心疾患の世界的,地域的,および国の負担,1990-2021年:分解,境界線,および予測分析

Xinyue Wen^1,2, Lichun Qiao², Feidan Deng²

¹Department of Psychiatry, The First Affiliated Hospital of Xi'an Jiaotong University, Xi An, Shaanxi, China.

Frontiers in public health

|September 3, 2025

まとめ

鉛の曝露は,世界的に心不全症 (IHD) に大きく寄与する. 低所得・中所得地域の男性や高齢者にとって標的型予防は不可欠です

科学分野:

環境健康
心血管疾患の疫学
毒理学について

背景:

発血性心臓病 (IHD) は世界的に大きな健康問題です
鉛の曝露は,IHDの流行に重大な環境リスク因子です.

研究の目的:

1990年から2021年にかけての鉛曝露によるIHD死亡と障害調整寿命 (DALYs) の世界,地域,および国の傾向を分析する.
鉛曝露に関連したIHD負担の主要な要因と人口格差を特定する.

主な方法:

グローバル・バード・オブ・ディジーズ・スタディ (GBD) 2021のデータを活用した.
分解分析,境界分析,ベイジアン年齢期コホート (BAPC) モデルを使用した.
鉛曝露によるIHDの評価傾向と予測された将来の負担

主要な成果:

2021年,鉛曝露は590,370人の死亡と11,854,611人のDALYを引き起こし,年齢標準化率 (ASR) は減少しています.
男性と高齢者のASRは高かった.南アジアが最も重く,北アフリカと中東が最も高かった.
平均的なSDI地域における死亡率/DALYの増加の主な要因は人口増加であり,2050年までに世界規模で減少すると予測されています.

結論:

鉛の曝露によるIHDの負担は,男性,高齢者,およびSDIが低から中程度の地域に不釣り合いに影響します.
標的を絞った予防と鉛曝露制御戦略は,これらの高リスク集団にとって不可欠です.
集中的な介入によって,SDIが低い地域におけるIHDの負担を軽減する大きな可能性が存在します.

キーワード:

死亡障害調整寿命年数全体的な負担発血性心臓病鉛への曝露

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