健康な男性における精液パラメータ値に対するCOVID-19の影響:単一センター,遡及的研究

Anil Erdik¹, Asli Merve Gokce², Ahmet Gokce³

¹Department of Urology, Karasu State Hospital, Sakarya, Turkey.

PeerJ

|September 3, 2025

まとめ

COVID-19の感染は男性の生殖能力に悪影響を及ぼします. ある研究では,軽度のCOVID-19を患った男性の40.9%が精子の質が低下し,運動能力と形状に影響したことが判明しました.

科学分野:

生殖医学
ウイルス学
アンドロロジー

背景:

新型コロナウイルス感染症2019 (COVID-19) は,男性の生殖健康に及ぼす潜在的な影響について懸念を喚起しています.
精子生成は,COVID-19のようなウイルス感染症に脆弱である可能性があります.

研究の目的:

軽度のCOVID-19が以前は正常な精液の質を持っていた男性の精子生成に与える影響を調査する.
精子パラメータに対するCOVID-19の潜在的亜急性効果を評価する.

主な方法:

RT-PCRで確認された軽度のCOVID-19を有する22人の男性患者 (年齢18〜48歳) を分析した遡及研究.
精液分析はCOVID-19感染前と診断後3ヶ月間に行われました.
排除基準には,入院,既にある不正常な精液パラメータ,または丸手術歴が含まれていた.

主要な成果:

22人の患者のうち9人 (40.9%) は,COVID-19感染後に少なくとも1つの不正常な精液パラメータを示した.
正常グループと比較して,COVID-19後に不正常な精液を持つ患者は,総精子運動量,進行性運動量,および正常な形状の有意な減少を示した.
不正常なグループでは,不動性の増加とアルカリ性の高い精液pHへの傾向が観察されました.

結論:

COVID-19の感染は精液の質に悪影響を及ぼし,男性の生育能力を損なう可能性があります.
COVID-19が精子形成に及ぼす長期的な影響を完全に理解するには,さらなる研究が必要です.

キーワード:

男性不妊症ノルモスペルミア SARS-CoV-2について精液分析

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