ヘモダイアリス患者におけるEnfortumab Vedotin Plus Pembrolizumabの安全性: 症例報告
Takafumi Mizuno1, Yuki Kobari1, Haruka Ito1
1Department of Urology, Tokyo Women's Medical University Hospital, Tokyo, Japan.
Cancer diagnosis & prognosis
|September 3, 2025
まとめ
エンフォルトゥマブ・ヴェドチンとペンブロリズマブ (EVP) は,血液透析を受けている患者の転移性尿路癌 (mUC) の第一線治療薬として利用可能である. このケーススタディは,EVPがこの集団で安全に投与され,管理可能な副作用があることを示しています.
科学分野:
- 腫瘍学
- 腎臓科
- 薬理学について
背景:
- 転移性泌尿器がん (mUC) は,効果的な第一線治療を必要とします.
- Enfortumab vedotin plus pembrolizumab (EVP) はmUCに対して承認されているが,血液透析を受けている患者は除外されている.
- 透析患者におけるEVPの安全性および有効性に関するデータは不足しています.
研究 の 目的:
- ヘモダイアリスを受けている転移性尿路がん (mUC) の患者におけるエンフォルトマブベドチンとペムブロリズマブ (EVP) の安全性と有効性を報告する.
- 透析中の患者に標準用 EVP を投与する可能性を評価する.
主な方法:
- ヘモダイアリスが必要な 72歳の男性の症例報告
- 標準用量でエンフォルトゥマブ・ヴェドチン (EV) とペムブロリズマブ (Pembro) を投与するファーストライン治療.
- 治療に関連する有害事象と疾患の進行をイメージングでモニタリングする.
主要な成果:
- EVPは3回投与され,投与量は減らなかった.
- 治療に関連した有害事象は,グレード2のとグレード1の疲労に限定された.
- 治療にも関わらず 骨髄の転移は拡大し 病気が進行していることを示しました
結論:
- 標準投与量であるエンフォルトゥマブ・ヴェドチンとペンブロリズマブ (EVP) は,血液透析中の転移性泌尿器官がん (mUC) の患者に安全に投与できるようです.
- 毒性は管理可能で,透析を受けていない患者との比較が可能でした.
- このケースでは抗腫瘍効果は確認されなかったが,EVPは,選択されたmUCの透析患者にとって治療の選択肢である可能性がある.
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