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Updated: Sep 9, 2025

High-throughput Screening for Broad-spectrum Chemical Inhibitors of RNA Viruses
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2'-デオキシ-2'-β-フッ素-4'-アジドシチジンまたはアズブジンによるウイルスポリメラーゼの阻害のメカニズムとスペクトル

Hery W Lee1, Egor P Tchesnokov1, Laura J Stevens2

  • 1Department of Medical Microbiology & Immunology, University of Alberta, Edmonton, AB T6G 2E1, Canada.

NAR molecular medicine
|September 3, 2025
PubMed
まとめ

アズブジントリホスファート (FNC- TP) はHIV-1および他のウイルスポリメラーゼを効果的に抑制し,広範囲の抗ウイルス能力を示しています. しかし,FNC-TPはSARS-CoV-2に対する活動性が低いため,COVID-19の治療に限られている.

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