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Updated: Sep 9, 2025

Activation of Apoptosis by Cytoplasmic Microinjection of Cytochrome c
07:42

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Published on: June 29, 2011

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KCC2の抑制とニューロンの過興奮は,C1qに依存する外部アポトーシスを促進する

Jinglin Ji1, Catherine Choi1, Christopher E Bope1

  • 1Department of Neuroscience, Tufts University School of Medicine, Boston, MA, United States.

Frontiers in molecular neuroscience
|September 3, 2025
PubMed
まとめ

神経細胞における塩化カリウム共伝達体2 (KCC2) 機能の喪失は,補足体C1qに依存する外的アポプトシス経路を通じて細胞死を誘発する. このKCC2/C1q複合体は,発作と興奮毒性の後のニューロンアポトーシスにおいて極めて重要です.

キーワード:
アポトーシスコンプリメント C1qエピレプシー神経免疫学カリウム塩化物共輸送機 2

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