機能性消化不良 (FD) の患者の睡眠質の低下 (PSQ) の流行: 体系的レビューとメタ解析
Rashmikaa Netyam1, Singam Shashank1, Chiranjeevee R Saravanan2
1General Medicine, Hampshire Hospitals, NHS Foundation Trust, Basingstoke, UK.
Annals of medicine and surgery (2012)
|September 3, 2025
まとめ
機能性消化不全 (FD) の患者の半数以上は,睡眠の質が悪い状態で,健康な人よりも睡眠障害を患う可能性が高い. 研究の限界のため,これらの発見を確認するためにさらなる研究が必要である.
科学分野:
- 胃腸内科
- 睡眠医学
- 公衆衛生
背景:
- 機能性消化不全 (FD) は,腹部上部の痛みと満腹を特徴とする一般的な胃腸疾患です.
- 睡眠の質の低下はしばしば機能性胃腸障害 (FGID) と関連しているが,FD患者のデータは限られている.
- この研究は,FDと診断された個体におけるPSQの罹患率を定量化することを目的とした.
研究 の 目的:
- 機能性消化不良 (FD) と診断された患者の間で睡眠質の低下 (PSQ) の集団的流行を決定する.
- 健康な対照群と比較して,FD患者のPSQのリスクを評価する.
- FDにおけるPSQに影響を与える潜在的な緩和要因を特定する.
主な方法:
- PubMed,Scopus,Web of Scienceで体系的な文献検索が行われました.
- FD患者におけるPSQの流行を報告した研究,または計算のための十分なデータを提供した研究が含まれていた.
- メタアナリシスは,メタリグレッションとモダレーターのためのサブグループ分析を使用して,流行データを集約し,オッズ比率を計算しました. 出版バイアスは,ファネルプロットとエッガーのテストを使用して評価されました.
主要な成果:
- 2138人のFD患者における睡眠の質の低下の総発生率は57. 2% (95%CI: 37% - 75. 2%) で,異質性が高い (I2 = 98. 4%).
- FD患者は,PSQのリスクが著しく高く,確率比は2. 39 (95%CI: 1. 86- 3. 06) で,異質性は低い (I2 = 1.73%).
- 集団的流行率の推定では,著しい出版バイアスが検出されました.
結論:
- 機能性消化不良の患者では,睡眠の質が悪いことが非常に多い.
- FD患者は健康な人と比較して睡眠不足のリスクが高い.
- 発見は高度な異質性および出版バイアスのために慎重に解釈されるべきであり,将来の研究は混同要因に対処し,診断を標準化すべきである.
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