ガンシクロウィール治療中のサイトメガロウイルス感染における局所的な侵入による突孔: 検死症例報告
Yoshitaka Ishiguro1, Akira Kuriyama1, Shingo Ishiguro2
1Department of Primary Care and Emergency Medicine, Kyoto University Hospital, Kyoto, Japan.
Annals of medicine and surgery (2012)
|September 3, 2025
まとめ
シトメガロウイルス (CMV) が高齢の女性でダイバーティキュラ perforation を引き起こした希少な症例が報告されています. ガンシクロビールの治療にも関わらず,局所的なCMVの侵入は穴を開け,珍しい臨床表現を強調した.
科学分野:
- 胃腸内科
- 感染症
- 病理学について
背景:
- サイトメガロウイルス (CMV) は,免疫不全の個体において大腸炎を一般的に引き起こします.
- 胃腸 perforation は CMV 大腸炎の希少な合併症であり,ダイバーティキュラー perforation は例外的にまれである.
- 免疫抑制療法を受けている自己免疫疾患の患者は,CMVのような機会性感染症のリスクがあります.
研究 の 目的:
- 高齢者のCMV誘発型脱節孔の報告
- 局所的なCMV侵入の臨床表現,病理的発見,および影響について議論する.
主な方法:
- 免疫抑制剤を服用した83歳の女性
- 内視鏡検査,CMV抗原血症検査,外科介入を含む臨床評価
- 検死と胃腸検査
主要な成果:
- 患者は重度の胃腸障害と 性ショックを示す症状を呈した.
- CMV大腸炎が確認され,ガンシクロビールの治療にも関わらず,ダイバーティキュラ perforation が発生しました.
- 組織病理学では,広範囲に広がった炎症なしに,穴開き部位で局所的なCMV感染細胞を明らかにした.
結論:
- CMV感染は,抗ウイルス療法中でも,局所的侵襲によって管の穿孔につながる可能性があります.
- このケースは CMV がリスクの高い患者の胃腸穴の原因であることの重要性を強調しています
- 侵入の局所的な性質は,CMV大腸炎の希少な臨床表現を表しています.
さらに関連する動画
関連する概念動画
Esophageal Perforation-II: Clinical Manifestations and Management
146
Esophageal perforations manifest in various clinical forms, influenced by factors such as the perforation's cause and location (cervical, intrathoracic, or intra-abdominal), the extent of contamination, and potential injury to adjacent mediastinal structures. The timing between the perforation occurrence and treatment initiation also affects the clinical presentation.
Clinical Manifestations:
Clinical Manifestations:
146
Esophageal Perforation-I: Introduction
167
Esophageal perforation is a severe medical condition characterized by a breach in the integrity of the esophageal wall. This breach can occur due to various factors such as trauma, medical procedures, or underlying diseases. When the esophageal wall is compromised, it allows food, fluids, and digestive juices into the chest cavity or adjacent structures, leading to potential complications and health risks.
The location of esophageal perforation can vary, occurring anywhere along the esophagus....
The location of esophageal perforation can vary, occurring anywhere along the esophagus....
167
Esophageal Varices-II: Clinical Features and Management
135
Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
135
Inflammatory Bowel Disease V: Surgical Management
206
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Here are some common surgical interventions for IBD:
206
Gastritis-II: Pathophysiology
542
Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
542
Appendicitis-II: Diagnostic Studies and Management
145
Diagnosing and managing appendicitis requires a structured and comprehensive approach that spans from initial assessment to postoperative care. Here is an overview of the process:
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
145


