中年および高齢者の高血圧と代謝パラメータとのクロノタイプ関連:横断的な研究

Ming-Jun Hu¹, Wen-Wen Hu², Bei Yao¹

¹Department of Health Management Center, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, People's Republic of China.

Nature and science of sleep

|September 3, 2025

まとめ

夜のクロノタイプは,高齢者の高血圧リスクと関連しています. コレステロールと尿酸のレベルを下げるような良質な代謝と相関しています

科学分野:

シルカディアン生物学
心血管の健康
代謝健康

背景:

クロノタイプは,睡眠と活動のタイミングに関する個人の日常的な日々の好みを記述します.
クロノタイプが健康に与える影響を理解することが重要です特に高齢者の場合です
高血圧と代謝失調は,中年および高齢者の健康上の重大な問題です.

研究の目的:

クロノタイプと高血圧リスクとの関連を調査する.
高齢者のクロノタイプと主要な代謝パラメータの関係を調べる.

主な方法:

945人の中年および高齢者が参加しました.
クロノタイプは,Morningness-Eveningness Questionnaireを使用して評価され,午前と夕方のタイプに分けられています.
多変量回帰と制限された立方筋分析は高血圧と代謝マーカーとの関連を評価した.

主要な成果:

夜間クロノタイプは高血圧リスクの上昇と有意に関連していた (OR=1. 60).
高度なクロノタイプスコアは,総コレステロール,LDL-C,血清尿酸の低下と相関する.
高いクロノタイプスコアはアスパルテートアミノトランスフェラーゼ濃度の上昇と関連していた.

結論:

夕方クロノタイプは高齢者の高血圧リスクを独立して予測する.
朝のクロノタイプは,低脂質と尿酸レベルを含む好ましい代謝プロファイルと関連しています.
クロノタイプは高血圧リスクの評価において重要で独立した要因である.

キーワード:

クロノタイプ高血圧メタボリックパラメータリスク要因寝る

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