肥満に関連する人体測定指標と慢性便秘および下痢の関連性:米国成人の横断的研究
Yu Ning1, Xiaoting Hu1, Laifu Li1
1Department of Gastroenterology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Frontiers in nutrition
|September 3, 2025
まとめ
肥満の指標である相対脂肪量 (RFM) と体重調整された腰指数 (WWI) は,米国の成人の腸疾患と関連しています. RFMは便秘を最もよく予測し WWIは下痢を最もよく予測し これらの状態を評価するのに役立ちます
科学分野:
- 公衆衛生と疫学
- 胃腸内科
- 肥満に関する研究
背景:
- 以前の研究では 肥満と便秘や下痢などの 腸の異常との関連が示されています
- しかし,これらの状態に関連した様々な肥満測定値の包括的な比較は限られている.
- この研究は,肥満の指標と腸疾患との関連を複数の測定値で比較する必要性について言及しています.
研究 の 目的:
- 肥満の複数の指標と アメリカ人の腹と便秘の流行の関連を調べる
- 慢性的な下痢や便秘の患者を特定する際の,様々な人体測定指標の診断性能を比較する.
- 腸内疾患を評価するための最も効果的な肥満測定法を特定する.
主な方法:
- 米国国民健康栄養調査 (NHANES) (2005年−2010年) の13,105人の成人 (年齢20歳以上) の横断データを使用した.
- ブリストル・ストール・フォーム・スケール (BSFS) を用いて排便習慣を評価し,7つの人体測定指標を分析した. 腰周量 (WC),体量指数 (BMI),相対脂肪量 (RFM),体丸さ指数 (BRI),体重調整された腰指数 (WWI),腰高比 (WHtR),体形指数 (ABSI).
- 加重された多変数ロジスティック回帰,制限された立方スライン (RCS) 分析,受信機動作特性 (ROC) 曲線分析 (曲線下の面積 [AUC]),サブグループ,および感度分析を使用した.
主要な成果:
- 7つの肥満指標は下痢と有意な正の関連性を示し,WWI (OR=1,937) とRFM (OR=1,870) が最も高い確率を示した.
- RFM,BRI,WC,BMI,WHtRは便秘と逆に関連しており (BMIとRFMのORは最も低い),ABSIは正の関連を示した.
- RFMは便秘 (AUC=0. 577) と,WWIは下痢 (AUC=0. 614) で最も高い判別能力を示した. RCS分析では,特定の関係パターン (例えば,RFM/便秘の逆J形,第一次世界大戦/下痢の線形) が明らかになった.
結論:
- 評価された7つの肥満指標は,米国の成人の腸内疾患の評価に価値があります.
- 相対脂肪量 (RFM) と体重調整された腰指数 (WWI) は,それぞれ便秘と下痢を識別する能力が最も強い.
- これらの発見は,腸の異常を特定し管理するために,臨床実務における特定の肥満測定の有用性を強調しています.
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