深層溶媒を用いたアトルバスタチンの溶解性の改善
Yoga Windhu Wardhana1,2, Insan Sunan Kurniawansyah1,2, Taofik Rusdiana1,2
1Department of Pharmaceutics and Pharmaceuticals Technology, Faculty of Pharmacy, Universitas Padjadjaran (UNPAD), Jatinangor, Indonesia.
Journal of advanced pharmaceutical technology & research
|September 3, 2025
まとめ
深層エウテクティック溶媒 (DES) はアトルバスタチンカルシウム三水素 (ATCH) の溶解性を高める. プロピレングリコール (PG) に含まれるニコチナミドは,ATCHの溶解性において最適であり,水に対する有意な改善を示した.
科学分野:
- 医薬品科学
- 材料科学
背景:
- ディープエウテクティック溶剤 (DES) は薬剤に潜力がありますが,安全性および使用可能性の評価が必要です.
- 薬剤の溶解性を改善することは 薬剤の有効な投与と製剤に不可欠です
研究 の 目的:
- アトルバスタチンカルシウム三水素 (ATCH) の溶解性を高めるためのDESの可能性を調査する.
- DESシステム内のニコチナミド (NA) のようなコフォーマーとATCHのユーテクティックな相互作用を探求する.
主な方法:
- 同結晶化原理を用いて ユーテクティック混合物を形成した.
- 偏光顕微鏡,フーリエ変換赤外線光譜 (FT-IR),微分スキャン熱計 (DSC) を分析に使用した.
- DESにおけるATCH,ニコチナミド (NA),プロピレングリコール (PG) の相互作用を評価した.
主要な成果:
- ニコチナミド (NA) をプロピレングリコール (PG) で利用した最適のDESシステムをATCHで特定した.
- FT-IRとDSC経由でATCHとDESの間の水素結合 (H結合) の形成が確認されました.
- 水 (0.000597 ± 0.003 mg/mL) と比較して,DESシステムにおけるATCH溶解性の有意な増加を示した.
結論:
- 特にニコチナミドがプロピレングリコールにおけるコフォーマーである深層エウテクティック溶媒は,アトルバスタチンカルシウム三水素の溶解性を効果的に高めます.
- この研究は,ATCHのような溶解性の低い薬剤の溶解性を改善するための実行可能な戦略として,DESの使用を検証しています.
- 水素結合の相互作用は,DESシステムで観察された溶解性の強化の鍵です.
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