代謝機能障害に関連した脂肪肝疾患と腸内機能不全の相互作用を調査する: 病理生理学,臨床的影響,新興治療法
Said A Al-Busafi1, Ahmed Alwassief2, Ali Madian3
1Department of Medicine, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat 123, Oman. busafis@squ.edu.om.
World journal of hepatology
|September 3, 2025
まとめ
代謝機能障害に関連した脂肪肝 (MAFLD) は,腸内微生物の変化によって引き起こされ,世界人口の4分の1に影響を及ぼします. 腸肝軸を標的とした介入は,MAFLDとその心代謝リスクの管理に有望である.
科学分野:
- ヘパトロジー
- 胃腸内科
- 微生物群の研究
背景:
- 代謝機能障害に関連した脂肪肝 (MAFLD) は,肥満とインスリン抵抗性に関連して,世界人口の25%に影響します.
- 腸肝軸はMAFLDの病原性の中心であり,腸内不活性症は肝損傷,炎症,および線維症を引き起こす.
- MAFLDは,微生物と胆酸の変化によるグルコースと脂質ホメオスタシスの障害によって心臓代謝リスクを悪化させる.
研究 の 目的:
- MAFLDの病原性における腸内微生物の役割を検討する.
- MAFLDにおける腸肝軸を標的とした新しい診断バイオマーカーと治療戦略を探求する.
- MAFLDの管理における課題と将来の方向性を議論する.
主な方法:
- MAFLDと不健康症,食事,生活習慣を関連付ける疫学研究のレビュー
- マイクロバイオーム由来バイオマーカーやマルチオミックパネルを含む新興の診断ツールの分析
- 微生物群を調節する介入の早期臨床試験データの評価
主要な成果:
- MAFLDのコホートは,ライフスタイルと宿主因子と相関する重要な腸の不活性化を示します.
- 前/前/共生薬やFMTのような微生物系ベースの診断と介入は,MAFLDの治療の可能性を示しています.
- 早期の介入により,MAFLD患者の組織学的および代謝的改善が期待されています.
結論:
- 腸肝軸と不活性化症は MAFLD 管理の重要なターゲットです.
- 微生物群の介入とライフスタイルの変化を組み合わせた 精密医療のアプローチは MAFLD の治療に最適です
- 民族間の多様性に対処し,治療アルゴリズムを確立し,微生物群ベースの治療法の規制上の障害を克服するためにさらなる研究が必要である.
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