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関連する概念動画

Auditory Pathway01:15

Auditory Pathway

5.8K
Auditory pathways constitute the complex neural circuits responsible for transmitting and interpreting auditory information from the peripheral auditory system to the brain. Sound waves are initially captured by the outer ear, funneled through the ear canal, and reach the tympanic membrane (eardrum). These vibrations are transmitted via the middle ear's ossicles to the inner ear's cochlea.
When viewed cross-sectionally, the cochlea reveals the scala vestibuli and scala tympani flanking...
5.8K
Anatomy of the Ear01:16

Anatomy of the Ear

8.9K
Auditory sensation, commonly called hearing, involves the transformation of sonic waves into neural impulses facilitated by the structures of the auditory organ. The prominent, flesh-like structure on the side of the head, called the auricle, directs sound waves towards the auditory canal. The auricle is often mislabeled as the pinna, a term more aligned with mobile structures like a feline's external ear. The auditory canal penetrates the cranium via the external auditory meatus of the...
8.9K
The Cochlea01:13

The Cochlea

45.8K
The cochlea is a coiled structure in the inner ear that contains hair cells—the sensory receptors of the auditory system. Sound waves are transmitted to the cochlea by small bones attached to the eardrum called the ossicles, which vibrate the oval window that leads to the inner ear. This causes fluid in the chambers of the cochlea to move, vibrating the basilar membrane.
45.8K
Hair Cells01:22

Hair Cells

41.3K
Hair cells are the sensory receptors of the auditory system—they transduce mechanical sound waves into electrical energy that the nervous system can understand. Hair cells are located in the organ of Corti within the cochlea of the inner ear, between the basilar and tectorial membranes. The actual sensory receptors are called inner hair cells. The outer hair cells serve other functions, such as sound amplification in the cochlea, and are not discussed in detail here.
41.3K
Hearing01:31

Hearing

53.0K
When we hear a sound, our nervous system is detecting sound waves—pressure waves of mechanical energy traveling through a medium. The frequency of the wave is perceived as pitch, while the amplitude is perceived as loudness.
53.0K
The Auditory Ossicles01:11

The Auditory Ossicles

1.9K
The auditory ossicles of the middle ear transmit sounds from the air as vibrations to the fluid-filled cochlea. The auditory ossicles consist of two malleus (hammer) bones, two incus (anvil) bones, and two stapes (stirrups), one on each side. These bones develop during the fetal stage and are the ones to ossify first. They are fully mature at birth and do not grow afterward.
The aptly named stapes look very much like a stirrup. The three ossicles are unique to mammals, and each plays a role in...
1.9K

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Updated: Sep 9, 2025

Dextran Labeling and Uptake in Live and Functional Murine Cochlear Hair Cells
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Dextran Labeling and Uptake in Live and Functional Murine Cochlear Hair Cells

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聴覚膜:構造,機能,そして聴覚障害への影響

Panpan Bian1, Jiong Dang1, Bai-Cheng Xu1

  • 1Department of Otolaryngology-Head & Neck Surgery, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, Gansu, China.

Frontiers in neurology
|September 3, 2025
PubMed
まとめ
この要約は機械生成です。

聴覚膜 (TM) は 聴覚に不可欠です 遺伝子や老化による 構造の障害は 聴覚障害につながりますが 遺伝子治療のような新しい治療法が 期待を寄せています

キーワード:
老化するコクリア遺伝子変異聴覚障害オート毒性テクトリアル膜甲状腺ホルモン

さらに関連する動画

Whole Mount Dissection and Immunofluorescence of the Adult Mouse Cochlea
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Whole Mount Dissection and Immunofluorescence of the Adult Mouse Cochlea

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Cochlear Surface Preparation in the Adult Mouse
09:51

Cochlear Surface Preparation in the Adult Mouse

Published on: November 6, 2019

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関連する実験動画

Last Updated: Sep 9, 2025

Dextran Labeling and Uptake in Live and Functional Murine Cochlear Hair Cells
05:55

Dextran Labeling and Uptake in Live and Functional Murine Cochlear Hair Cells

Published on: February 8, 2020

7.5K
Whole Mount Dissection and Immunofluorescence of the Adult Mouse Cochlea
12:02

Whole Mount Dissection and Immunofluorescence of the Adult Mouse Cochlea

Published on: January 1, 2016

56.1K
Cochlear Surface Preparation in the Adult Mouse
09:51

Cochlear Surface Preparation in the Adult Mouse

Published on: November 6, 2019

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科学分野:

  • 耳鼻喉科
  • 細胞生物学
  • 遺伝学

背景:

  • テクトリアル膜 (TM) は,聴覚処理に不可欠な,大腸内の重要な細胞外マトリックスです.
  • 耳鳴りのメカニズムと音の増幅における その正確な役割は 聴覚にとって極めて重要です
  • テクトリアル膜に関連した聴覚障害の原因となるメカニズムは完全に理解されていません.

研究 の 目的:

  • 組織膜の構造と機能を見直す
  • 聴覚信号の増幅におけるTMの役割について
  • TM 機能障害と潜在的な治療戦略に寄与する要因について議論する.

主な方法:

  • テクトリアル膜の構造,機能,聴覚障害に関する研究の文献レビュー.
  • TMの整体性に対する遺伝的要因,老化,ホルモンの影響の分析.
  • 現行および新興の診断および治療アプローチの検討.

主要な成果:

  • TM組成の異常 (コラーゲン,グリコサミノグリカン,タンパク質) は聴覚障害に関連しています.
  • TECTA,TECTB,CEACAM16のような遺伝子の変異は TMの完全性を破壊し,神経感覚の聴覚障害を引き起こします.
  • 老化と甲状腺ホルモンの欠乏が TM 退化に寄与する.

結論:

  • 聴覚膜の整合性は正常な聴覚に不可欠です
  • 遺伝子変異,老化,ホルモンの不均衡が TMの構造と機能に大きく影響します.
  • 遺伝子治療と幹細胞治療は,TMに関連した聴覚障害の将来的な治療法です.