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関連する概念動画

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Pigmentation01:19

Pigmentation

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The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
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Abnormal Proliferation02:23

Abnormal Proliferation

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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
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Papillary Dermis01:11

Papillary Dermis

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Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
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Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
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Non-LTR Retrotransposons03:18

Non-LTR Retrotransposons

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As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
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関連する実験動画

Updated: Sep 9, 2025

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
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Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

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PRAME 繰り返し発生する/持続するメラノサイトス・ネヴィの表現

Alison H Kucharik1, Helana Ghali2, Doniya Milani1,3

  • 1Department of Dermatology and Cutaneous Surgery, University of South Florida, Tampa, FL.

The American Journal of dermatopathology
|September 3, 2025
PubMed
まとめ
この要約は機械生成です。

PRAME免疫ヒストケミストリーは,再発性メラノサイト性ネビの診断に有用である. この染色は良性ネビとメラノーマを区別し,診断の信頼性を高め,不必要な処置を減らすことができます.

キーワード:
PRAME について再発性ネブス

さらに関連する動画

The Three-Dimensional Human Skin Reconstruct Model: a Tool to Study Normal Skin and Melanoma Progression
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A 3D Organotypic Melanoma Spheroid Skin Model
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A 3D Organotypic Melanoma Spheroid Skin Model

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Last Updated: Sep 9, 2025

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
06:09

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Published on: June 7, 2019

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The Three-Dimensional Human Skin Reconstruct Model: a Tool to Study Normal Skin and Melanoma Progression
11:02

The Three-Dimensional Human Skin Reconstruct Model: a Tool to Study Normal Skin and Melanoma Progression

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A 3D Organotypic Melanoma Spheroid Skin Model
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A 3D Organotypic Melanoma Spheroid Skin Model

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科学分野:

  • 皮膚病理学
  • 免疫ヒストケミストリー
  • 腫瘍学

背景:

  • 再発性メラノサイト性ネビは非典型的特徴を呈し,特に生検情報がない場合,診断を複雑にします.
  • PReferentially expressed Antigen in MElanoma (PRAME) ステインはメラノーマの診断に使用されているが,再発性ネビにおけるその役割は不明である.

研究 の 目的:

  • 良性の再発性メラノサイト性ネビとメラノーマの区別におけるPRAME免疫ヒストケミストリーの有用性を評価する.
  • 元のネヴィと再発したネヴィの間のPRAME表現の一貫性を評価する.

主な方法:

  • 22人の患者のペア化された原発性および再発性メラノサイト性ネビのPRAME発現を分析した.
  • 染色濃度,陽性メラノサイトの割合,複合スコアを用いて評価されたPRAME免疫ヒストケミストリー.

主要な成果:

  • PRAMEの発現パターンは,元のネヴィと再発したネヴィの間で一貫していました.
  • 分析されたすべての症例は,原発的および再発性ネヴィの両方で,PRAME染色の複合スコアが否定的でした.

結論:

  • PRAME免疫ヒストケミストリーは,良性的な再発性ネビをメラノーマと区別する有用性を示しています.
  • 再発性ネビにおける一貫した負のPRAME複合スコアは,診断の信頼性を高め,不必要な処置を避けるのに役立ちます.