炎症は,表 epithelial-mesenchymal 現象状態を調節することによって,休眠している癌細胞を覚醒させます

Jingwei Zhang¹, Jingwen Zhang^2,3,4,5,6, Longfei Han^2,3,4,5

¹Whitehead Institute for Biomedical Research, Cambridge, MA 02142.

Proceedings of the National Academy of Sciences of the United States of America

|September 3, 2025

まとめ

肺の炎症は休眠している乳がん細胞を目覚めさせ再発を引き起こしますこのような細胞は腫瘍を形成する能力を獲得し周囲からの信号も受けずに生存し続けます

科学分野:

腫瘍学
細胞生物学
免疫学

背景:

臨床的な再発は休眠状態にあるがん細胞の目覚めによるものです
癌細胞の休眠状態と覚醒のメカニズムを理解することは転移性再発を防ぐために極めて重要です

研究の目的:

眠っている乳がん細胞が肺の微小環境で覚醒するメカニズムを研究する
休眠状態の癌細胞が増殖や腫瘍発生状態に移行する要因を特定する.

主な方法:

マウスモデルを使って肺の乳がん細胞を研究しました
ブレオミシンによる肺炎治療の副作用を模倣した
癌細胞の覚醒に関与する現象的変化と分子信号伝達経路を分析した.

主要な成果:

肺に潜伏している乳がん細胞は増殖しないメゼンキマ状態で存在します
ブレオミシンによって引き起こされる肺炎は眠っている細胞を効果的に目覚めさせます
覚醒した細胞は準メゼンキマ状態に変化し腫瘍発生性と増殖能力を獲得する.
特にM2マクロファージからの表皮成長因子受容体リガンドは,この移行を促進します.

結論:

転移性覚醒は炎症のような外的要因によって引き起こされ癌細胞内部のプロセスによってのみ引き起こされるものではありません
覚醒した癌細胞は継続的な微小環境信号から独立して腫瘍を誘発する能力を維持できます
炎症を誘発する要因と関連するシグナル伝達経路をターゲットにすることで癌の再発を防ぐ新しい戦略が提供されるかもしれません

キーワード:

乳がん癌の休眠状態と目覚め癌の転移エピテリア・メセンキマの移行腫瘍の微小環境

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