関連する実験動画

Updated: Sep 9, 2025

Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes
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Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes

Published on: June 3, 2018

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プロコラーゲンIIAは,マウスの心臓発作転写ネットワークのポジティブフィードバック制御を媒介する

Alan W Leung1, Sandra Y Wong1, Janet C Zhang2

  • 1School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China.

Proceedings of the National Academy of Sciences of the United States of America
|September 3, 2025
PubMed
まとめ

IIA型プロコラーゲン (IIA) は,心臓の発達に不可欠であり,心臓の転写因子とBMP/TGFβシグナル伝達とのフィードバックループで作用する. IIAの喪失は,先駆者の発達を阻害し,出血管の欠陥を引き起こし,先天性心臓病の予防におけるその役割を強調します.

キーワード:
心臓増強剤細胞外マトリックス心臓の発達トランスクリプション 規制タイプIIプロコラーゲン

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