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Updated: Sep 9, 2025

High Throughput In Vitro Assessment of Latency Reversing Agents on HIV Transcription and Splicing
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High Throughput In Vitro Assessment of Latency Reversing Agents on HIV Transcription and Splicing

Published on: January 22, 2019

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HIV-1アクセサリータンパク質Vprは,CD4+T細胞におけるヒストン脱エチラゼによってブロックされる,暗号的p300依存の転写促進活性を有する

Catherine A Lewis1,2, David M Margolis1,2,3, Edward P Browne1,2,3

  • 1Department of Microbiology and Immunology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, United States of America.

PLoS pathogens
|September 3, 2025
PubMed
まとめ

HIV付属タンパク質Vprは,ウイルスの発現を促進し,中央記憶CD4+T細胞の潜伏貯蔵庫を選択し,ヒストン脱酸化酵素 (HDACs) は,この活動を制限する. これらの相互作用を理解することは HIVの潜伏期間の新しい治療法の開発の鍵です

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